Results 81 to 90 of about 1,849,278 (326)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Evolutionary learning in neural networks by heterosynaptic plasticity

open access: yesiScience
Summary: Training biophysical neuron models provides insights into brain circuits’ organization and problem-solving capabilities. Traditional training methods like backpropagation face challenges with complex models due to instability and gradient issues.
Zedong Bi   +5 more
doaj   +1 more source

Geometric principles of second messenger dynamics in dendritic spines. [PDF]

open access: yes, 2019
Dendritic spines are small, bulbous protrusions along dendrites in neurons and play a critical role in synaptic transmission. Dendritic spines come in a variety of shapes that depend on their developmental state.
Bartol, Thomas M   +4 more
core   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu   +10 more
wiley   +1 more source

Are some individuals generally more behaviorally plastic than others? An experiment with sailfin mollies [PDF]

open access: yesPeerJ, 2018
Individuals within the same population generally differ among each other not only in their behavioral traits but also in their level of behavioral plasticity (i.e., in their propensity to modify their behavior in response to changing conditions).
Julie Gibelli   +2 more
doaj   +2 more sources

Revisiting Stability Criteria in Ball‐Milled High‐Entropy Alloys: Do Hume–Rothery and Thermodynamic Rules Equally Apply?

open access: yesAdvanced Engineering Materials, Volume 27, Issue 6, March 2025.
The stability criteria affecting the formation of high‐entropy alloys, particularly focusing in supersaturated solid solutions produced by mechanical alloying, are analyzed. Criteria based on Hume–Rothery rules are distinguished from those derived from thermodynamic relations. The formers are generally applicable to mechanically alloyed samples.
Javier S. Blázquez   +5 more
wiley   +1 more source

Energetic Approach to Large Strain Gradient Crystal Plasticity

open access: yesActa Polytechnica, 2012
We formulate a problem of the evolution of elasto-plastic materials subjected to external loads in the framework of large deformations and multiplicative plasticity.
Jan Kratochvíl, Martin Kružík
doaj  

Extra plasticity governed by shear band deflection in gradient metallic glasses

open access: yesNature Communications, 2022
Materials with controlled structural gradient have gained attention due to their unique combinations of properties. Here the authors report strategies to design controllable gradients in bulk metallic glasses, demonstrating extra plasticity and ...
Yao Tang   +7 more
doaj   +1 more source

Strain gradient polycrystal plasticity for micro-forming [PDF]

open access: yesAIP Conference Proceedings, 2016
The developments in the micro-device industry has produced a substantial demand for the miniaturized metallic components with ultra-thin sheet materials that have thickness dimensions on the order of 50-500 µm which are produced through micro-forming processes.
Yalcinkaya, Tuncay   +2 more
openaire   +3 more sources

A finite element framework for distortion gradient plasticity with applications to bending of thin foils [PDF]

open access: yes, 2016
A novel general purpose Finite Element framework is presented to study small-scale metal plasticity. A distinct feature of the adopted distortion gradient plasticity formulation, with respect to strain gradient plasticity theories, is the constitutive ...
E. Mart'inez-Paneda   +2 more
semanticscholar   +1 more source

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