Results 71 to 80 of about 632,931 (308)
Cell Systems, 2015 The new associate vice chancellor of computational heath sciences at the University of California San Diego reflects on the coming era of big data in medicine.
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CoRR, 2016 Gradients have been used to quantify feature importance in machine learning models. Unfortunately, in nonlinear deep networks, not only individual neurons but also the whole network can saturate, and as a result an important input feature can have a tiny gradient.
Mukund Sundararajan +2 more
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Formation of thebicoidmorphogen gradient: an mRNA gradient dictates the protein gradient [PDF]
Development, 2009 The Bicoid (Bcd) protein gradient is generally believed to be established in pre-blastoderm Drosophila embryos by the diffusion of Bcd protein after translation of maternal mRNA, which serves as a strictly localized source of Bcd at the anterior pole.
Spirov, A +5 more
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Higher modes in the near surface: the influence of gradients
SeismicaHigher modes of surface waves are more sensitive to the details of the wavespeed distribution with depth than the fundamental modes, and in particular to the wavespeed gradients within layers and the transition between layers.
Brian L. N. Kennett
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Travelling gradients in interacting morphogen systems [PDF]
, 2007 Morphogen gradients are well known to play several important roles in development; however the mechanisms underlying the formation and maintenance of these gradients are often not well understood.
Maini, P. K. +3 more
core +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Super-Low Dose Lipopolysaccharide Dysregulates Neutrophil Migratory Decision-Making
Frontiers in Immunology, 2019 Neutrophils are the first responders to infection and play a pivotal role in many inflammatory diseases, including sepsis. Recent studies have shown that lipopolysaccharide (LPS), a classical pattern recognition molecule, dynamically programs innate ...
Brittany P. Boribong +3 more
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Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Using light to shape chemical gradients for parallel and automated analysis of chemotaxis
Molecular Systems Biology, 2015 Numerous molecular components have been identified that regulate the directed migration of eukaryotic cells toward sources of chemoattractant. However, how the components of this system are wired together to coordinate multiple aspects of the response ...
Sean R Collins +5 more
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