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Acute graft versus host disease [PDF]
Orphanet Journal of Rare Diseases, 2007 Acute graft-versus-host disease (GVHD) occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins with the preparative regimen. About 35%-50% of hematopoietic stem cell transplant (HSCT) recipients
Georgia B. Vogelsang, David A. Jacobsohn
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NOTCH and Graft-Versus-Host Disease [PDF]
Frontiers in Immunology, 2018 In allogeneic hematopoietic stem cell transplantation, which is the major curative therapy for hematological malignancies, T cells play a key role in the development of graft-versus-host disease (GvHD). NOTCH pathway is a conserved signal transduction system that regulates T cell development and differentiation.
Mauro Di Ianni +15 more
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Human Graft Versus Host Disease
Journal of Investigative Dermatology, 1980 Human graft versus host disease is composed of 2 distinct clinical entities, acute graft versus host disease and chronic graft versus host disease, which have different pathogenesis. Acute graft versus host disease is produced by the attack of donor immunocompetent T or null lymphocytes against recipient histocompatibility antigens.
Joel M. Rappeport +2 more
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Transplantation, 1968 Graft-versus-host disease was induced in adult hybrid rats by injection of spleen cells from either or both parental strains. Under the conditions of these experiments, GVH disease infiltrates appeared in the hepatic portal areas in all rats splenectomized before injection, but rarely in intact or sham-operated animals.
Seymour Levine
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Graft-versus-host disease [PDF]
Case Reports, 2010 This article presents the case of a 26-year-old man who was diagnosed with pneumatosis cystoides intestinalis, a rare consequence of colonic graft-versus-host disease, after CT imaging revealed free air tracking within the bowel wall and abdomen. His presentation with hiccups, abdominal and neck distension, along with diarrhoea was also unusual, and ...
Satyajit Sahu +4 more
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Graft-Versus-Host Disease: A Review [PDF]
Journal of the Royal Society of Medicine, 1987 A. John Barrett
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Hematology/Oncology Clinics of North America, 1990 Graft-versus-host disease (GVHD) is caused by immunologic recognition of the patient by the donor marrow graft after allogeneic bone marrow transplantation. Despite advances in understanding and new agents and methods to treat GVHD, the disease and complications related to it and its treatment are the principal causes of death after transplantation ...
Georgia B. Vogelsang, John E. Wagner
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Graft-versus-host disease [PDF]
The Lancet, 2009 Haemopoietic-cell transplantation (HCT) is an intensive therapy used to treat high-risk haematological malignant disorders and other life-threatening haematological and genetic diseases. The main complication of HCT is graft-versus-host disease (GVHD), an immunological disorder that affects many organ systems, including the gastrointestinal tract ...
Ernst Holler +3 more
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Graft-versus-host disease [PDF]
Journal of the American Academy of Dermatology, 2012 Approximately 25,000 allogeneic hematopoietic cell transplants are performed worldwide each year for a variety of malignant and non-malignant conditions. Graft-versus-host disease represents one of the most frequent complications and is a major source of long-term morbidity and mortality.
Amin M. Alousi +2 more
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Graft versus host disease [PDF]
Journal of the American Academy of Dermatology, 1981 Graft versus host disease (GVHD) occurs in 50% to 70% of patients receiving bone marrow transplants. It can also develop in immunosuppressed patients with malignancies who receive nonirradiated blood transfusions. Most work indicates that the primary mechanism of GVHD is cell-mediated. It is likely that humoral factors are involved as well.
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