Results 21 to 30 of about 332,661 (303)

Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation [PDF]

, 2020
Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1) is an enzyme that converts cholesterol to cholesteryl esters. A recent in vivo study reported that inhibiting ACAT1 enzyme activity upregulates the membrane cholesterol levels of T cells, enhancing ...
Okuno, Shingo, Kamoshita, Sonoko, Goto, Tatsunori, Miyamura, Koichi, Miyao, Kotaro, Kiyoi, Hitoshi, Koyama, Daisuke, Julamanee, Jakrawadee, Murata, Makoto, Ozawa, Yukiyasu, Terakura, Seitaro, Nishida, Tetsuya, Takagi, Erina   +12 more
core   +1 more source

PET assessment of acute gastrointestinal graft versus host disease [PDF]

, 2023
Acute gastrointestinal graft versus host disease (GI-GVHD) is a common complication following allogeneic haematopoietic cell transplantation (HCT), and is characterised by severe morbidity, frequent treatment-refractoriness, and high mortality.
Glen A. Kennedy, Siok-Keen Tey, Henden, Andrea, Kennedy, Glen AA, Ashleigh P. Scott, Scott, Ashleigh PP, Andrea Henden, Tey, Siok-Keen   +7 more
core   +1 more source

Breakdown of thymic tolerance - an etiologic link between acute and chronic graft-versus-host disease [PDF]

, 2014
Allogeneic haematopoietic stem cell transplantation (HSCT) is the standard therapy for many disorders of the haematological system. Its use is limited by the major complication acute graft-versus-host disease (GVHD). Development of acute GVHD predisposes
Dertschnig, Simone
core   +1 more source

Cytokines in Graft-versus-Host Disease [PDF]

The Journal of Immunology, 2015
Abstract Graft-versus-host disease (GVHD) is a complication of allogeneic bone marrow transplantation whereby transplanted naive and marrow-derived T cells damage recipient tissue through similar mechanisms to those that allow destruction of malignant cells, the therapeutic intent of bone marrow transplantation.
Henden, Andrea S., Hill, Geoffrey R.
openaire   +5 more sources

Graft versus host disease after liver transplantation following radiotherapy for the treatment of hepatocellular carcinoma: A case report and literature review

SAGE Open Medical Case Reports, 2022
Graft versus host disease after solid organ transplantation is very rare. This article reports a case of graft versus host disease after liver transplantation following targeted therapy and radiotherapy for the treatment of hepatocellular carcinoma.
Zijun Chen, Chuangye Han, Xiangkun Wang, Yongfei He, Tianyi Liang, Shutian Mo, Xuan Li, Guangzhi Zhu, Hao Su, Xinping Ye, Zili Lv, Liming Shang, Zhang Wen, Minhao Peng, Tao Peng   +14 more
doaj   +1 more source

Vitiligo: an uncommon cutaneous manifestation of graft versus host disease

Pigment International, 2022
Graft versus host disease (GVHD) is the most serious complication of hematopoietic stem cell transplantation. Skin is the most commonly affected organ, in both acute and chronic GVHD with a variable clinical spectrum of presentation with the typical skin
Preema Sinha, Anwita Sinha, Subramaniyan Radhakrishnan, Jasvinder Kaur Bhatia   +3 more
doaj   +1 more source

The global severity of chronic graft-versus-host disease, determined by National Institutes of Health consensus criteria, is associated with overall survival and non-relapse mortality

Haematologica, 2011
Background The 2005 National Institutes of Health Consensus Development Conference on chronic graft-versus-host disease proposed major changes in the classification and grading of severity of chronic graft-versus-host disease.Design and Methods We aimed ...
Joseph Pidala, Jongphil Kim, Claudio Anasetti, Taiga Nishihori, Brian Betts, Teresa Field, Janelle Perkins   +6 more
doaj   +1 more source

When donor T cells attack: The curious case of liver transplant-associated acute graft-versus-host-disease

Science Progress, 2022
Graft versus host disease is a rare but deadly complication of solid organ transplant. Clinical features of graft-versus-host-disease are non-specific, which may lead to delayed diagnosis as more common conditions including infections or drug reactions ...
Max Deschner, Donald J. Bastin, Ziad Solh, Karen Bosma, Wael Haddara, Ping Yang, Robert Broadbent, Aaron Haig, Jonathan Keow, Mayur Brahmania, Anargyros Xenocostas, Uday Deotare   +11 more
doaj   +1 more source

Graft-versus-Host Disease: Review [PDF]

, 2019
Graft-versus-host Disease (GVHD) is a major complication with high morbidity and mortality rates on patients undergoing hematopoietic stem cell transplantation.
Tulio Batista Abud (6543074), Antonio Di Zazzo (827192), Lauro Augusto de Oliveira (4958032), Luciene Barbosa de Sousa (4958035)   +3 more
core   +1 more source

Recombinant human thrombopoietin reduces the risk of acute graft-versus-host-disease and its mechanisms [PDF]

, 2023
Recombinant human thrombopoietin reduces the risk of acute graft-versus-host-disease and its mechanismsObjective: Acute graft-versus-host-disease (aGVHD) is an important complication that is observed after allogeneic hematopoietic stem cell ...
Hairong Fei (16720680), Sizhou Feng (15204806), Chunting Zhao (818245), Xiaolin Ma (701778), Xiaodan liu (5541338), Erlie Jiang (4040900)   +5 more
core   +1 more source