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Graft-versus-host disease [PDF]
The Lancet, 2009 Haemopoietic-cell transplantation (HCT) is an intensive therapy used to treat high-risk haematological malignant disorders and other life-threatening haematological and genetic diseases. The main complication of HCT is graft-versus-host disease (GVHD), an immunological disorder that affects many organ systems, including the gastrointestinal tract ...
James L M, Ferrara +3 more
openaire +2 more sources
Frontiers in Immunology, 2020 Chronic graft-versus-host-disease (cGVHD) is the leading cause of late non-relapse mortality after allogeneic hematopoietic stem cell transplantation(HSCT). There is no standard therapy for patients refractory or dependent to corticosteroid treatment. We
Liren Qian +4 more
doaj +1 more source
Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation [PDF]
, 2020 Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1) is an enzyme that converts cholesterol to cholesteryl esters. A recent in vivo study reported that inhibiting ACAT1 enzyme activity upregulates the membrane cholesterol levels of T cells, enhancing ...
Okuno, Shingo +12 more
core +1 more source
Ocular graft-versus-host disease: An update on immune pathogenesis and therapies
Medicina Universitaria, 2022 Hematopoietic stem cell transplantation (HSCT) is a treatment option for hematological and non-hematological diseases that do not respond to conventional treatments.
Samantha P. Peña-Lozano +3 more
doaj +1 more source
Current Opinion in Oncology, 1990 Graft-versus-host disease (GVHD) is caused by immunologic recognition of the patient by the donor marrow graft after allogeneic bone marrow transplantation. Despite advances in understanding and new agents and methods to treat GVHD, the disease and complications related to it and its treatment are the principal causes of death after transplantation ...
G B, Vogelsang, J E, Wagner
openaire +4 more sources
Cytokines in Graft-versus-Host Disease [PDF]
The Journal of Immunology, 2015 Abstract Graft-versus-host disease (GVHD) is a complication of allogeneic bone marrow transplantation whereby transplanted naive and marrow-derived T cells damage recipient tissue through similar mechanisms to those that allow destruction of malignant cells, the therapeutic intent of bone marrow transplantation.
Henden, Andrea S., Hill, Geoffrey R.
openaire +5 more sources
Haematologica, 2018 Upper gastrointestinal acute graft-versus-host disease is reported in approximately 30% of hematopoietic stem cell transplant recipients developing acute graft-versus-host disease.
Sarah Nikiforow +28 more
doaj +1 more source
Cutaneous graft-versus-host disease after hematopoietic stem cell transplant - a review [PDF]
Anais Brasileiros de Dermatologia, 2016 Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplants (allo-HSCT) associated with significant morbidity and mortality. The earliest and most common manifestation is cutaneous graft-versus-host disease.
Cesar Daniel Villarreal Villarreal +3 more
doaj +1 more source
Breakdown of thymic tolerance - an etiologic link between acute and chronic graft-versus-host disease [PDF]
, 2014 Allogeneic haematopoietic stem cell transplantation (HSCT) is the standard therapy for many disorders of the haematological system. Its use is limited by the major complication acute graft-versus-host disease (GVHD). Development of acute GVHD predisposes
Dertschnig, Simone
core +1 more source
Vitiligo: an uncommon cutaneous manifestation of graft versus host disease
Pigment International, 2022 Graft versus host disease (GVHD) is the most serious complication of hematopoietic stem cell transplantation. Skin is the most commonly affected organ, in both acute and chronic GVHD with a variable clinical spectrum of presentation with the typical skin
Preema Sinha +3 more
doaj +1 more source