Results 11 to 20 of about 332,330 (302)
NOTCH and Graft-Versus-Host Disease [PDF]
Frontiers in Immunology, 2018 In allogeneic hematopoietic stem cell transplantation, which is the major curative therapy for hematological malignancies, T cells play a key role in the development of graft-versus-host disease (GvHD).
Mauro Di Ianni +15 more
doaj +4 more sources
Human Graft Versus Host Disease
Journal of Investigative Dermatology, 1980 Human graft versus host disease is composed of 2 distinct clinical entities, acute graft versus host disease and chronic graft versus host disease, which have different pathogenesis.
Robertson Parkman +5 more
core +3 more sources
Acute graft versus host disease [PDF]
Orphanet Journal of Rare Diseases, 2007 Acute graft-versus-host disease (GVHD) occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins
Vogelsang Georgia B, Jacobsohn David A
doaj +3 more sources
PLoS ONE, 2021 Graft-versus-host disease is a major complication after allogeneic hematopoietic stem cell transplantation for hematological malignancies. Immunosuppressive drugs, such as anti-thymocyte globulin, alemtuzumab, and post-transplant cyclophosphamide, have ...
Kiyomi Mashima +17 more
doaj +1 more source
Current Opinion in Oncology, 1990 Graft-versus-host disease (GVHD) is caused by immunologic recognition of the patient by the donor marrow graft after allogeneic bone marrow transplantation. Despite advances in understanding and new agents and methods to treat GVHD, the disease and complications related to it and its treatment are the principal causes of death after transplantation ...
G B, Vogelsang, J E, Wagner
openaire +4 more sources
Frontiers in Immunology, 2020 Chronic graft-versus-host-disease (cGVHD) is the leading cause of late non-relapse mortality after allogeneic hematopoietic stem cell transplantation(HSCT). There is no standard therapy for patients refractory or dependent to corticosteroid treatment. We
Liren Qian +4 more
doaj +1 more source
Graft-versus-host disease [PDF]
BMJ Case Reports, 2010 This article presents the case of a 26-year-old man who was diagnosed with pneumatosis cystoides intestinalis, a rare consequence of colonic graft-versus-host disease, after CT imaging revealed free air tracking within the bowel wall and abdomen. His presentation with hiccups, abdominal and neck distension, along with diarrhoea was also unusual, and ...
Joel A, Newman +4 more
openaire +2 more sources
Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation [PDF]
, 2020 Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1) is an enzyme that converts cholesterol to cholesteryl esters. A recent in vivo study reported that inhibiting ACAT1 enzyme activity upregulates the membrane cholesterol levels of T cells, enhancing ...
Okuno, Shingo +12 more
core +1 more source
Graft-versus-host disease [PDF]
The Lancet, 2009 Haemopoietic-cell transplantation (HCT) is an intensive therapy used to treat high-risk haematological malignant disorders and other life-threatening haematological and genetic diseases. The main complication of HCT is graft-versus-host disease (GVHD), an immunological disorder that affects many organ systems, including the gastrointestinal tract ...
James L M, Ferrara +3 more
openaire +2 more sources
SAGE Open Medical Case Reports, 2022 Graft versus host disease after solid organ transplantation is very rare. This article reports a case of graft versus host disease after liver transplantation following targeted therapy and radiotherapy for the treatment of hepatocellular carcinoma.
Zijun Chen +14 more
doaj +1 more source