Results 51 to 60 of about 179,002 (365)

Surgically treated genital chronic graft‐versus‐host disease in women: A report of three cases [PDF]

, 2021
Hematopoietic stem cell transplantation (HSCT) is a crucial treatment for hematological malignancy. Gonadal dysfunction occurs at an early stage after this treatment, and such patients may require hormone replacement therapy. Genital chronic graft-versus-
Kamada, Yasuhiko, Kashino, Chiaki, Kubo, Kotaro, Kusumoto, Rie, Masuyama, Hisashi, Mitsui, Takashi   +5 more
core   +1 more source

Common human diseases prediction using machine learning based on survey data [PDF]

arXiv, 2022
In this era, the moment has arrived to move away from disease as the primary emphasis of medical treatment. Although impressive, the multiple techniques that have been developed to detect the diseases. In this time, there are some types of diseases COVID-19, normal flue, migraine, lung disease, heart disease, kidney disease, diabetics, stomach disease,
arxiv  

High pre-transplant serum nitrate levels predict risk of acute steroid-refractory graft-versus-host disease in the absence of statin therapy

Haematologica, 2014
Steroid-refractory graft-versus-host disease is a life-threatening complication after allogeneic stem cell transplantation. Evidence is accumulating that steroid-refractory graft-versus-host disease is associated with endothelial distress.
Sascha Dietrich, Jürgen G. Okun, Kathrin Schmidt, Christine S. Falk, Andreas H. Wagner, Suzan Karamustafa, Aleksandar Radujkovic, Ute Hegenbart, Anthony D. Ho, Peter Dreger, Thomas Luft   +10 more
doaj   +1 more source

The role of mutation rate variation and genetic diversity in the architecture of human disease [PDF]

, 2013
We have investigated the role that the mutation rate and the structure of genetic variation at a locus play in determining whether a gene is involved in disease. We predict that the mutation rate and its genetic diversity should be higher in genes associated with disease, unless all genes that could cause disease have already been identified ...
arxiv   +1 more source

Unveiling new disease, pathway, and gene associations via multi-scale neural networks [PDF]

PLOS ONE, 15(4), p.e0231059 (2020), 2019
Diseases involve complex processes and modifications to the cellular machinery. The gene expression profile of the affected cells contains characteristic patterns linked to a disease. Hence, biological knowledge pertaining to a disease can be derived from a patient cell's profile, improving our diagnosis ability, as well as our grasp of disease risks ...
arxiv   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, Volume 599, Issue 7, Page 927-951, April 2025.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

Mesenchymal stromal cells transiently alter the inflammatory milieu post-transplant to delay graft-versus-host disease

Haematologica, 2010
Background Multipotent mesenchymal stromal cells suppress T-cell function in vitro, a property that has underpinned their use in treating clinical steroid-refractory graft-versus-host disease after allogeneic hematopoietic stem cell transplantation ...
Melinda E. Christensen, Brie E. Turner, Laura J. Sinfield, Katarina Kollar, Hannah Cullup, Nigel J. Waterhouse, Derek N.J. Hart, Kerry Atkinson, Alison M. Rice   +8 more
doaj   +1 more source

Chronic graft-versus-host disease

Biology of Blood and Marrow Transplantation, 2003
Chronic graft-versus-host disease (GVHD) remains a vexing and dangerous complication of allogeneic stem cell transplantation. Mild forms of chronic GVHD are often manageable with local or low-dose systemic immunosuppression and do not affect long-term survival.
Georgia B. Vogelsang, Stephanie J. Lee, Mary E.D. Flowers   +2 more
openaire   +2 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, Volume 19, Issue 5, Page 1532-1545, May 2025.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source