Results 111 to 120 of about 5,921,684 (304)

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Predictors of cognitive function in candidates for coronary artery bypass graft surgery

, 2007
Predictors of cognitive function in candidates for coronary artery bypass graft ...
MUC Worcester (14449266), CS Ernest (15836381), Michael Le Grande (13085268), J Tatoulis (13417257), BM Murphy (14112315), AJ Goble (15836342), PC Elliott (15836345), RO Higgins (14447523)   +7 more
core  

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

Tacrolimus to belatacept conversion in proteinuric kidney transplant recipients

Frontiers in Immunology
BackgroundProteinuria is associated with worse allograft outcomes in kidney transplant recipients (KTRs) and treatment strategies are limited. We examined the outcomes of calcineurin inhibitor (CNI) to belatacept conversion in proteinuric KTRs.MethodsIn ...
Orhan Efe, Ayman Al Jurdi, Morgan Mabey Eiting, Christine Rogers Marks, Mariesa Ann Cote, David Wojciechowski, Kassem Safa, Hannah Gilligan, Jamil Azzi, Nitender Goyal, Marc Raynaud, Alexandre Loupy, Astrid Weins, Leonardo V. Riella, Leonardo V. Riella   +14 more
doaj   +1 more source

BuMPy road of delayed graft function

American Journal of Physiology-Renal Physiology, 2012
delayed graft function (DGF) occurs in 20–30% of renal transplants and contributes significantly to the gradual loss of grafts through accelerated development of chronic allograft dysfunction. Members of the transforming growth factor-β (TGF-β) family are incriminated as the major driving force for developing fibrosis.
openaire   +3 more sources

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Enhancing Liver Transplant Outcomes through Liver Precooling to Mitigate Inflammatory Response and Protect Mitochondrial Function

Biomedicines
Transplanted organs experience several episodes of ischemia and ischemia-reperfusion. The graft injury resulting from ischemia-reperfusion (IRI) remains a significant obstacle to the successful survival of transplanted grafts.
Minh H. Tran, Jie Gao, Xinzhe Wang, Ruisheng Liu, Colby L. Parris, Carlos Esquivel, Yingxiang Fan, Lei Wang   +7 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Kidney transplantation in Icelandic patients, 2000–2019: are outcomes affected by low volume?

Frontiers in Transplantation
BackgroundIn Iceland, a small number of kidney transplants from living donors (LDs) are performed at Landspitali University Hospital (LUH) in Reykjavik, while deceased donor transplants have until recently invariably been carried out abroad.
Thordur P. Palsson, Margret B. Andresdottir, Eirikur Jonsson, Johann Jonsson, Johann Jonsson, Rafn Hilmarsson, Olafur S. Indridason, Runolfur Palsson, Runolfur Palsson   +8 more
doaj   +1 more source