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Current Opinion in Immunology, 1994
Although chronic rejection remains the most crucial cause of organ graft loss over the long term, its etiology is not well defined. Early injury to graft endothelial cells caused by alloantigen-independent factors, such as ischemia or reperfusion, as well as alloantigen-dependent events, such as acute rejection, have been implicated.
H. Azuma, Nicholas L. Tilney
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Although chronic rejection remains the most crucial cause of organ graft loss over the long term, its etiology is not well defined. Early injury to graft endothelial cells caused by alloantigen-independent factors, such as ischemia or reperfusion, as well as alloantigen-dependent events, such as acute rejection, have been implicated.
H. Azuma, Nicholas L. Tilney
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Survey of Ophthalmology, 2007
Penetrating keratoplasty is the most widely practiced type of transplantation in humans. Irreversible immune rejection of the transplanted cornea is the major cause of human allograft failure in the intermediate and late postoperative period. This immunological process causes reversible or irreversible damage to the grafted cornea in several cases ...
Amit Kumar +4 more
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Penetrating keratoplasty is the most widely practiced type of transplantation in humans. Irreversible immune rejection of the transplanted cornea is the major cause of human allograft failure in the intermediate and late postoperative period. This immunological process causes reversible or irreversible damage to the grafted cornea in several cases ...
Amit Kumar +4 more
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Skin Grafting and Graft Rejection in Goats
American Journal of Veterinary Research, 1978SUMMARY As part of a study to define the major histocompatibility complex of the goat and to show certain aspects of its biological function, a skin-grafting technique is described which might also be applicable for similar studies in other ruminant species.
van Dam, RH +3 more
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The pharmacology of graft rejection
Trends in Pharmacological Sciences, 1979Abstract Graft rejection is a complex reaction and although the immunology is well understood, the pharmacology of graft rejection is still in its early days. We have tried to review the pharmacological studies that are contributing towards a better understanding of this reaction.
G.P. Lewis, Beverley A. Mangham
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American Journal of Ophthalmology, 1986
Four patients (three women and one man, 30 to 63 years old) developed increased intraocular pressure during graft rejection reactions. The increased intraocular pressure returned to normal in one case after successful treatment of the immune reaction but a second patient required antiglaucoma medication for a short period.
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Four patients (three women and one man, 30 to 63 years old) developed increased intraocular pressure during graft rejection reactions. The increased intraocular pressure returned to normal in one case after successful treatment of the immune reaction but a second patient required antiglaucoma medication for a short period.
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Placental hormones and graft rejection
American Journal of Obstetrics and Gynecology, 1969Abstract To explore the possibility that the placenta prevents its own immunologic rejection by the mother by producing a “hormonal barrier” either locally or systemically, rabbits undergoing skin allograft exchanges were given placental hormones either systemically or at graft sites.
Jaroslav F. Hulka, Kathleen Mohr
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The Immunology of Corneal Graft Rejection
Critical Reviews™ in Immunology, 1998Corneal transplantation is the most successful of organ transplants due to the fact that the eye is an immunologically privileged site, and the cornea is an immunologically privileged tissue. The factors responsible for this include presence of the blood-aqueous barrier, the avascularity of the cornea, the absence of classic antigen-presenting cells ...
Guillermo Rocha +2 more
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The Pattern of Corneal Graft Rejection
Cornea, 1990A series of 160 consecutive penetrating keratoplasties was analysed for patterns of graft rejection. All surgery was performed between January 1981 and December 1987. The incidence of homograft rejection was 34% (54 grafts). The site of the initial rejection episode was analysed.
W. F.I. Shepherd, G. N. Kervick
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Science, 2002
IMMUNOLOGY Achieving immune tolerance to transplanted tissues remains a major hurdle in organ transplantation. Increasingly, it is becoming clear that protocols aimed at improving graft-specific tolerance will need to consider regulatory T cells, because these lymphocytes are known to be important in suppressing immune responses. Graca et al.
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IMMUNOLOGY Achieving immune tolerance to transplanted tissues remains a major hurdle in organ transplantation. Increasingly, it is becoming clear that protocols aimed at improving graft-specific tolerance will need to consider regulatory T cells, because these lymphocytes are known to be important in suppressing immune responses. Graca et al.
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Innate immunity and graft rejection
Immunological Reviews, 2000Summary: Although innate immunity evolved to combat pathogens, increasing awareness of a pivotal role in driving and shaping adaptive immunity has prompted this review on the role of innate immunity in graft rejection. We present evidence that grafts, especially xenografts, elicit innate responses, required for adaptive immunity.
Annette Fox, Leonard C. Harrison
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