Results 21 to 30 of about 7,846,955 (114)

Prolonged sirolimus administration after allogeneic hematopoietic cell transplantation is associated with decreased risk for moderate-severe chronic graft-versus-host disease

Haematologica, 2015
Effective pharmacological strategies employed in allogeneic hematopoietic cell transplantation should prevent serious chronic graft-versus-host disease and facilitate donor-recipient immune tolerance.
Joseph Pidala, Jongphil Kim, Melissa Alsina, Ernesto Ayala, Brian C. Betts, Hugo F. Fernandez, Teresa Field, Heather Jim, Mohamed A. Kharfan-Dabaja, Frederick L. Locke, Asmita Mishra, Taiga Nishihori, Leonel Ochoa-Bayona, Lia Perez, Marcie Riches, Claudio Anasetti   +15 more
doaj   +1 more source

Donor characteristics and hematopoietic stem cell transplantation outcome: experience of a single center in Southern Brazil

Hematology, Transfusion and Cell Therapy, 2018
Background: Hematopoietic stem cell transplantation is a curative treatment for many patients with hematological disorders. Donor–recipient genetic disparity, especially involving the human leukocyte antigen system is a critical factor for transplant ...
Alessandra Paz, Lisandra Rigoni, Gustavo Fischer, Monise Schittler, Annelise Pezzi, Vanessa Valim, Alice Dahmer, Bruna Zambonato, Bruna Amorin, Filipe Sehn, Maria Aparecida da Silva, Liane Daudt, Lucia Silla   +12 more
doaj   +1 more source

Bendamustine Conditioning Skews Murine Host DCs Toward Pre-cDC1s and Reduces GvHD Independently of Batf3

Frontiers in Immunology, 2020
Graft-versus-host disease (GvHD) remains the second leading cause of death in allogeneic hematopoietic stem cell transplantation recipients, highlighting the need for improved preventative strategies.
Megan S. Molina, Megan S. Molina, Jessica Stokes, Emely A. Hoffman, Jelena Eremija, Yi Zeng, Yi Zeng, Richard J. Simpson, Richard J. Simpson, Richard J. Simpson, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis   +14 more
doaj   +1 more source

Transfusion-associated graft-vs-host disease – A case report [PDF]

, 2016
Transfusion-associated graft-vs-host disease (TAGVHD) is a rare complication of blood transfusion. Unlike GVHD associated with hematopoietic stem cell transplantation TA-GVHD involves the patient's bone marrow and leads to bone marrow aplasia.
Bhattacharyya, Jina; Department of Clinical Hematology, Gauhati Medical College, Guwahati, India, Dutta, Sangit; Department of Medicine, Gauhati Medical College, Guwahati, India, Kakati, Bhaskar Jyoti; International Hospital, Guwahati, India, Bhattacharyya, Mrinal; International Hospital, Guwahati, India, Raj, Aishwarya; Department of Clinical Hematology, Gauhati Medical College, Guwahati, India, Khound, Nilom; International Hospital, Guwahati, India   +5 more
core   +1 more source

Severe acute graft versus host disease after lung transplant: report of a case successfully treated with high dose corticosteroids

, 2009
Acute graft vs host disease is an uncommon and usually fatal complication of lung transplant for which no effective therapy exists. All 8 patients with grade 3 to 4 acute graft vs host disease after lung transplantation described in literature died ...
LAGHI PASINI F., FILIPPI R., LUZZI L., FOSSI A., VOLTOLINI L., MARCHI B., ROTTOLI P., GOTTI G., Luca Luzzi, Franco Laghi Pasini, Antonella Fossi, Voltolini, Luca, Luca Voltolini, Bruna Marchi, Giuseppe Gotti, Rita Filippi, Paola Rottoli   +16 more
core   +2 more sources

Treatment of Severe Steroid-Refractory Acute-Graft-vs.-Host Disease With Mesenchymal Stem Cells–Single Center Experience [PDF]

, 2018
The most effective treatment of steroid refractory acute graft vs. host disease (aGvHD) is not yet established and mesenchymal stem cells (MSC) appear to be a promising therapy for the condition. We report single center case series of three patients, who
Miomir Kneževič, Simona L. Avčin, Maja Česen Mazič, Lenart Girandon, Janez Jazbec   +4 more
core   +1 more source

Mesenchymal stromal cells transiently alter the inflammatory milieu post-transplant to delay graft-versus-host disease [PDF]

, 2010
Background Multipotent mesenchymal stromal cells suppress T-cell function in vitro, a property that has underpinned their use in treating clinical steroid-refractory graft-versus-host disease after allogeneic hematopoietic stem cell transplantation ...
K. Atkinson, Turner, Brie E., K. Kollar, L. J. Sinfield, Kollar, Katarina, Cullup, Hanna, Sinfield, Laura J., B. E. Turner, H. Cullup, N. J. Waterhouse, Hart, Derek N. J., Atkinson, Kerry, Rice, Alison M., M. E. Christensen, Christensen, Melinda E., Hart, Derek N.J., A. M. Rice, Waterhouse, Nigel J., D. N. J. Hart, Cullup, Hannah   +19 more
core   +1 more source

Consensus on graft-versus-host disease

Journal of Bone Marrow Transplantation and Cellular Therapy
Graft-versus-host disease (GvHD) remains the mainly cause of late non-relapse mortality following allogeneic hematopoietic cell transplantation. Advancements in novel immunosuppressive therapies and prophylactic regimens necessitate an update to current ...
Vaneuza Araújo Moreira Funke, João Victor Piccolo Feliciano, Giancarlo Fatobene, Maria Cláudia Rodrigues Moreira, Antonio Vaz de Macedo, Rita de Cássia Barbosa da Silva Tavares, Marcia de Matos Silva, Marcos Paulo Colella, Morgani Rodrigues, Luis Fernando da Silva Bouzas, Afonso Celso Vigorito   +10 more
doaj   +1 more source

Optimizing Transplant Approaches and Post-Transplant Strategies for Patients With Acute Myeloid Leukemia

Frontiers in Oncology, 2021
Acute Myeloid Leukemia (AML) is the commonest indication for allogeneic stem cell transplantation (allo-SCT) worldwide. The increasingly important role of allo-SCT in the management of AML has been underpinned by two important advances.
Justin Loke, Justin Loke, Hrushikesh Vyas, Hrushikesh Vyas, Charles Craddock, Charles Craddock   +5 more
doaj   +1 more source

Inflammatory Cytokine Networks in Gastrointestinal Tract Graft vs. Host Disease

Frontiers in Immunology, 2019
Graft vs. host disease (GVHD) is the major non-relapse complication associated with allogeneic hematopoietic stem cell transplantation (HSCT). Damage to the gastrointestinal (GI) tract from acute GVHD is a particularly serious event that can result in ...
Clint Piper, William R. Drobyski, William R. Drobyski   +2 more
doaj   +1 more source