Ruxolitinib in refractory acute and chronic graft-versus-host disease: a multicenter survey study [PDF]
, 2020 Graft-versus-host disease is the main cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. First-line treatment is based on the use of high doses of corticosteroids.
López Corral, Lucía +8 more
core +6 more sources
Therapeutic Potential of a Senolytic Approach in a Murine Model of Chronic GVHD
Biology, 2023 Graft-versus-host disease (GVHD) is a life-threatening systemic complication of allogeneic hematopoietic stem cell transplantation (HSCT) characterized by dysregulation of T and B cell activation and function, scleroderma-like features, and multi-organ ...
Deepika Raman +7 more
doaj +1 more source
Role of HRCT Chest in Post Stem Cell Transplant Recipients Suspected of Pulmonary Complications [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Stem cell transplantation is today’s procedure of choice for management of various hematopoietic malignant and severe immunogenic disorders. High Resolution Computed Tomography (HRCT) is a common technique for the diagnosis of pulmonary
Abhishek Dwivedi +3 more
doaj +1 more source
Small Bowel Perforation Associated With Gastrointestinal Graft-Versus-Host Disease and Cytomegalovirus Enteritis in a Patient With Leukemia: A Case Report With Literature Review [PDF]
Annals of Coloproctology, 2020 Gastrointestinal graft-versus-host disease (GVHD) is a common complication after hematopoietic stem cell transplantation. Concomitant cytomegalovirus (CMV) enteritis worsens the prognosis of this condition.
Kwang-Seop Song +9 more
doaj +1 more source
Rehabilitation in Children With Sclerodermoid Chronic Graft-Versus-Host Disease: Case Series [PDF]
Annals of Rehabilitation Medicine, 2019 Joint contracture in chronic graft-versus-host disease (cGVHD) is refractory to treatment, and tends to deteriorate gradually over time. There is scant clinical research focusing on timing and intensity of rehabilitation on joint contractures in children
Minji Jung, In Young Sung, Eun Jae Ko
doaj +1 more source
Prevention of graft-vs.-host disease [PDF]
Expert Opinion on Pharmacotherapy, 2012 Allogeneic hematopoietic cell transplantation (HCT) is a curative treatment for many malignant and non-malignant hematologic disorders. However, graft-vs.-host disease (GVHD) remains a major complication of allogeneic HCT and limits the success of this approach.This paper reviews recent developments in the prevention of acute and chronic GVHD.
Andrew R, Rezvani, Rainer F, Storb
openaire +2 more sources
Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation [PDF]
, 2020 Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1) is an enzyme that converts cholesterol to cholesteryl esters. A recent in vivo study reported that inhibiting ACAT1 enzyme activity upregulates the membrane cholesterol levels of T cells, enhancing ...
Okuno, Shingo +12 more
core +1 more source
Umbilical cord blood transplantation: Still growing and improving
Stem Cells Translational Medicine, 2021 Umbilical cord blood transplantation (UCBT) has been performed in the clinic for over 30 years. The biological and immunological characteristics of umbilical cord blood (UCB) have been re‐recognized in recent years.
Xiaoyu Zhu, Baolin Tang, Zimin Sun
doaj +1 more source
Acetabular Insufficiency Fractures in the Setting of Graft vs Host Disease: A Report of Two Cases
Arthroplasty Today, 2021 We report a case series of 2 patients with unilateral acetabular insufficiency fractures who received allogeneic peripheral blood stem cell transplantation for hematologic malignancies complicated by chronic graft vs host disease. These were managed with
Warren Nielsen, BS, Kathryn Schabel, MD
doaj +1 more source
Revista Brasileira de Hematologia e Hemoterapia, 2011 BACKGROUND: The lack of standardization of clinical diagnostic criteria, classification and severity scores of chronic graft-versus-host disease led the National Institutes of Health to propose consensus criteria for the purpose of clinical trials ...
Rita de Cássia Barbosa da Silva Tavares +14 more
doaj +1 more source