Results 21 to 30 of about 7,425,086 (301)

Umbilical cord blood transplantation: Still growing and improving

Stem Cells Translational Medicine, 2021
Umbilical cord blood transplantation (UCBT) has been performed in the clinic for over 30 years. The biological and immunological characteristics of umbilical cord blood (UCB) have been re‐recognized in recent years.
Xiaoyu Zhu, Baolin Tang, Zimin Sun
doaj   +1 more source

Acetabular Insufficiency Fractures in the Setting of Graft vs Host Disease: A Report of Two Cases

Arthroplasty Today, 2021
We report a case series of 2 patients with unilateral acetabular insufficiency fractures who received allogeneic peripheral blood stem cell transplantation for hematologic malignancies complicated by chronic graft vs host disease. These were managed with
Warren Nielsen, BS, Kathryn Schabel, MD
doaj   +1 more source

Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation [PDF]

, 2020
Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1) is an enzyme that converts cholesterol to cholesteryl esters. A recent in vivo study reported that inhibiting ACAT1 enzyme activity upregulates the membrane cholesterol levels of T cells, enhancing ...
Okuno, Shingo, Kamoshita, Sonoko, Goto, Tatsunori, Miyamura, Koichi, Miyao, Kotaro, Kiyoi, Hitoshi, Koyama, Daisuke, Julamanee, Jakrawadee, Murata, Makoto, Ozawa, Yukiyasu, Terakura, Seitaro, Nishida, Tetsuya, Takagi, Erina   +12 more
core   +1 more source

Brazilian workshop model to train investigators in chronic graft-versus-host disease clinical trials according to the 2005-2006 National Institutes of Health recommendations

Revista Brasileira de Hematologia e Hemoterapia, 2011
BACKGROUND: The lack of standardization of clinical diagnostic criteria, classification and severity scores of chronic graft-versus-host disease led the National Institutes of Health to propose consensus criteria for the purpose of clinical trials ...
Rita de Cássia Barbosa da Silva Tavares, Márcia de Matos Silva, Luis Fernando da Silva Bouzas, Maria Cláudia Rodrigues, Afonso Celso Vigorito, Vaneusa Funke, Marcos Mauad, Maria Elvira Pizzigatti Correa, Clarissa Vasconcellos de Souza, Elenaide Nunes, Alessandra Ferrari, Ariana Paixão, Talita Martins, Érika Pallottino, Mary Evelyn Dantas Flowers   +14 more
doaj   +1 more source

Post-transplant cyclophosphamide versus anti-thymocyte globulin as graft- versus-host disease prophylaxis in haploidentical transplant

Haematologica, 2017
Severe graft-versus-host disease is a major barrier for non-T-cell-depleted haploidentical stem cell transplantation. There is no consensus on the optimal graft-versus-host disease prophylaxis.
Annalisa Ruggeri, Yuqian Sun, Myriam Labopin, Andrea Bacigalupo, Francesca Lorentino, William Arcese, Stella Santarone, Zafer Gülbas, Didier Blaise, Giuseppe Messina, Ardeshi Ghavamzadeh, Florent Malard, Benedetto Bruno, Jose Luis Diez-Martin, Yener Koc, Fabio Ciceri, Mohamad Mohty, Arnon Nagler   +17 more
doaj   +1 more source

Breakdown of thymic tolerance - an etiologic link between acute and chronic graft-versus-host disease [PDF]

, 2014
Allogeneic haematopoietic stem cell transplantation (HSCT) is the standard therapy for many disorders of the haematological system. Its use is limited by the major complication acute graft-versus-host disease (GVHD). Development of acute GVHD predisposes
Dertschnig, Simone
core   +1 more source

A prospective randomized trial comparing cyclosporine/methotrexate and tacrolimus/sirolimus as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell transplantation

Haematologica, 2016
Improvement of graft-versus-host disease prophylaxis remains an important goal in allogeneic hematopoietic stem cell transplantation. Based on reports of possibly preferential properties of sirolimus, we compared the standard regimen of cyclosporine and ...
Johan Törlén, Olle Ringdén, Karin Garming-Legert, Per Ljungman, Jacek Winiarski, Kari Remes, Maija Itälä-Remes, Mats Remberger, Jonas Mattsson   +8 more
doaj   +1 more source

One-way donor-to-recipient human leukocyte antigen mismatch and graft-versus-host disease in liver transplantation: an observational study of a single-center experience in Korea

Korean Journal of Transplantation, 2023
Background : Graft-versus-host disease (GVHD) is a rare, but potentially fatal complication of liver transplantation. One-way human leukocyte antigens (HLA) mismatch has emerged as a risk factor for GVHD.
Seung Hyuk Yim, Deok-Gie Kim, Jae Geun Lee, Dong Jin Joo, Myoung Soo Kim   +4 more
doaj   +1 more source

Targeting the Human T-Cell Inducible COStimulator Molecule with a Monoclonal Antibody Prevents Graft-vs-Host Disease and Preserves Graft vs Leukemia in a Xenograft Murine Model

Frontiers in Immunology, 2017
BackgroundGraft-vs-host disease (GVHD) is a major complication of allogenic bone marrow transplantation (BMT). Targeting costimulatory molecules with antagonist antibodies could dampen the excessive immune response that occurs, while preserving the ...
Aude Burlion, Simon Brunel, Nicolas Y. Petit, Daniel Olive, Gilles Marodon   +4 more
doaj   +1 more source

Chronic graft-versus-host disease – the role of dermatological treatment [PDF]

, 2017
Introduction . The number of allogeneic haematopoietic stem cell transplantations is increasing year by year. The most common long-term complication is chronic graft-versus-host disease, with skin involvement noted in over 90% of cases. Objective . To
Joanna Gruber-Kopczyńska, Magdalena Żychowska, Małgorzata Tupikowska-Marzec, Joanna Maj   +3 more
core   +1 more source