Results 31 to 40 of about 46,902 (266)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Ordered coalescence of nano-crystals in alkaline niobate ceramics with high remanent polarization

Journal of Materiomics, 2017
Lead-free alkali niobates Na0.5K0.5NbO3 (NKN) ceramics, with significantly enhanced ferroelectric remanent polarization (Pr), were prepared using Spark Plasma Sintering (SPS).
Zhijian Shen, Daniel Grüner, Mirva Eriksson, Lyubov M. Belova, Ce-Wen Nan, Haixue Yan   +5 more
doaj   +1 more source

Deformation Behavior and Microstructure Evolution of CoCrNi Medium-Entropy Alloy Shaped Charge Liners

Metals, 2022
To investigate the microstructure evolution and dynamic deformation behavior of a CoCrNi medium entropy alloy under an ultrahigh explosive loading rate, CoCrNi-shaped charged liners were fabricated and fired into steel targets.
Jian Chen, Tian-Wei Liu, Fu-Hua Cao, Hai-Ying Wang, Yan Chen, Lan-Hong Dai   +5 more
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Wetting Effects at a Grain Boundary

Physical Review Letters, 2004
We consider a tier of weakened bonds along the center line of a two-dimensional Ising ferromagnet strip as a model of a grain boundary. When an interface traverses such a strip at an angle, whether or not there is a continuous pinning-depinning transition at subcritical temperature depends on this angle and the degree of bond weakening.
Abraham, D.B., Mustonen, V., Wood, A.J.
openaire   +4 more sources

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source

Nanotwinning: Generation, properties, and application

Materials & Design, 2020
In recent years, nanotwinned (NT) materials have attracted great attention in several research areas because of many advantageous properties (e.g., high conductivity, excellent mechanical stability, and distinctive structure).
Prateek Uttam, Vanish Kumar, Ki-Hun Kim, Akash Deep   +3 more
doaj   +1 more source

Grain boundaries in semiconductors

Journal of Physics C: Solid State Physics, 1985
This review presents the available experimental and theoretical understanding on the structure and electronic properties of grain boundaries in semiconducting materials. High-resolution electron microscope images of interfaces are interpreted within the framework of the structural unit model of grain boundaries, and the electronic properties of the ...
openaire   +2 more sources