Results 151 to 160 of about 576,900 (305)

Transthyretin is a novel innate immune effector against Gram negative bacteria. [PDF]

PLoS Pathog
Bernabé T, Verd M, Ramis G, González-Alsina A, Qadi M, Mateu-Borrás M, Doménech-Sánchez A, Albertí S.   +7 more
europepmc   +1 more source

Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice

Advanced Healthcare Materials, EarlyView.
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec, Randy Lee, Jingming Cao, Sophie Marolleau, Julien Nicolas, Sébastien Benzekry   +5 more
wiley   +1 more source

Surface protein machineries in Gram-negative bacteria. [PDF]

J Cell Sci
Overly Cottom C, Billings E, Bush M, DRozario D, Scherschel W, Noinaj N.   +5 more
europepmc   +1 more source

Oxygen Supply of Islets of Langerhans by Photosynthetically Active Microalgae in Bioprinted Co‐Cultures Maintains Their Function in a Hypoxic Environment

Advanced Healthcare Materials, EarlyView.
This study developed a bioprinted co‐culture system embedding rat pancreatic islets and Scenedesmus sp. microalgae spatially defined in close vicinity. Red light was found optimal to ensure microalgal photosynthesis while maintaining islet viability and functionality. A tailored co‐culture medium supported both cell types.
Finn Dani, Sarah Duin, Ashwini Rahul Akkineni, Susann Lehmann, Barbara Ludwig, Michael Kühl, Michael Gelinsky, Anja Lode   +7 more
wiley   +1 more source

Gram-Negative Septicemia

Annals of Surgery, 1967
W A, Altemeier, J C, Todd, W W, Inge
openaire   +5 more sources

Leclercia adecarboxylata: A Rare and Emerging Cause of Gram-Negative Infective Endocarditis. [PDF]

Cureus
Al-Shujairi O, Srirathan V, Rumjaun MK, Price F.   +3 more
europepmc   +1 more source

A Physiological Microfluidic Blood–Brain‐Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation

Advanced Healthcare Materials, EarlyView.
A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen, Neona M. Lowe, Sophia Kellogg, Kuan‐Wei Huang, Hannah O'Toole, Elizabeth J. Hale, Venktesh S. Shirure, Bhupinder S. Shergill, Steven C. George, Randy P. Carney   +9 more
wiley   +1 more source

Fosfomycin Use in Treating Severe Difficult-to-Treat Gram-Negative Infections-A Comprehensive Review. [PDF]

Antibiotics (Basel)
Koulenti D, Timsit JF.
europepmc   +1 more source

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

The Quantification of Drug Accumulation within Gram-Negative Bacteria. [PDF]

ACS Infect Dis
George A, Shivangi, Bozan A, Spencer K, Terlecky AJ, Ahn YM, Barnett PR, Kreiswirth BN, Freundlich JS.   +8 more
europepmc   +1 more source