Results 171 to 180 of about 612,577 (265)

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

Infection prevention and control strategies for multidrug-resistant Gram-negative bacteria in healthcare: a narrative review. [PDF]

JAC Antimicrob Resist
Weston G, Nori P, Singh HK, Woods KL, Lee R, Frech Preciado E, Halim J, Alp Mese E, Weber DJ.   +8 more
europepmc   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

Response of Caenorhabditis elegans during subsequent infections with Gram positive and Gram negative bacteria

BMC Infectious Diseases, 2012
Mercy Gnanasekaran, Balamurugan Krishnaswamy   +1 more
doaj   +1 more source

Occurrence and Antimicrobial Resistance Profiles of Culturable Ampicillin-Resistant Gram-Negative Bacteria in the Ring of Cenotes Aquifer, Yucatán, Mexico. [PDF]

Microorganisms
Vargas-Gutiérrez P, Ramírez-Trujillo JA, Busto-Ulloa A, Lozano-Aguirre L, Téllez-Sosa J, Bocanegra-Ibarias P, Lizama-Uc G, Hernández-Lucas I, Suárez-Rodríguez R, Duran-Bedolla J, Barrios-Camacho H.   +10 more
europepmc   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

An Overview of Mobile Colistin Resistance (mcr) Genes in Gram-Negative Bacilli. [PDF]

Cureus
Yadav MV, Pawar S, Patil S.
europepmc   +1 more source

Spatiotemporally Ultrasound‐Controlled Nanoparticles Reprogramming Immunostimulatory Antigen‐Presenting Cancer‐Associated Fibroblasts to Enhance Cancer Immunotherapy

Advanced Science, EarlyView.
We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai, Weikai Sun, Yuxuan Zhao, Daqian Sun, Ting Meng, Yafei Qi, Fengyang Jiang, Jintang Sun, Zhiliang Gao, Dexin Yu   +9 more
wiley   +1 more source

Editorial: Small non-coding RNAs in Gram negative bacteria

Frontiers in Cellular and Infection Microbiology
Bindu Subhadra, Meysam Sarshar
doaj   +1 more source

Gram-Positive and Gram-Negative Probiotic Extracellular Vesicles: Mechanisms of Immune Modulation and Therapeutic Opportunities in Atopic Dermatitis. [PDF]

Clin Rev Allergy Immunol
Wayal V, Lee MF, Wang JY, Chen YH.
europepmc   +1 more source