Results 191 to 200 of about 612,577 (265)

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

Advanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu, Xiaodong Luo, Jingxian Wu, Chaoyang Huang, Zhuoying Yang, Yixiang HePeng, Bosong Zhou, Xiang Li, Ruiyuan Liu, Xu Wu   +9 more
wiley   +1 more source

Novel Fluorinated Chlorhexidine Analogues Overcome Resistance in Gram-Negative Bacteria. [PDF]

ACS Omega
Li Y, Jajja M, Lu J, Chowdhury NS, Hind C, Sutton JM, Rahman KM.   +6 more
europepmc   +1 more source

Green and Scalable Synthesis of Efficient and Stable CsPbBr3 Perovskite Quantum Dots Enables Low‐Threshold Amplified Spontaneous Emission

Advanced Science, EarlyView.
Green and scalable synthesis of CsPbBr3 perovskite quantum dots using bio‐sourced lecithin and hexane enables single‐batch production over 10 grams. Suppressed Auger recombination and electron‐phonon coupling yields 95% PLQY, enhanced stability, and low ASE thresholds of 230.4 (ns) and 50.1 (fs) µJ cm−2 in neat films. ABSTRACT Halide perovskite quantum
Yongfeng Liu, Mengting Zhang, Qingyu Xie, Kehao Hu, Bowen Zhang, Zhe Zhang, Jie Yang, Zhiping Hu, Juan Du, Jia Wang, Min Zhou   +10 more
wiley   +1 more source

Discovery and Optimization of Novel Nonhydroxamate LpxC Inhibitors for the Treatment of Multidrug-Resistant Gram-Negative Infections. [PDF]

J Med Chem
Martin DP, Teng M, Nammalwar B, Perez C, Li X, Munguia J, Taganov K, Fan J, Agarwalla S, Lonergan D, Tomaras AP, Zimmerman Z, Puerta DT.   +12 more
europepmc   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Empirical Antibiotic Activity and Outcomes in Pediatric Gram-negative Bloodstream Infections: A Rank-based Composite Outcome Analysis. [PDF]

Clin Infect Dis
Wen SCH, Hardy MJ, Aslan AT, Harris PNA, Chatfield MD, Lau CL, Spurling G, Clark JE, Dougherty S, Blyth CC, Britton PN, Clifford V, Haeusler GM, McMullan B, Wadia U, Schlapbach L, Chambers H, Paterson DL, Irwin AD, PAEDS Network.   +19 more
europepmc   +1 more source

Which Bacterial Agent Is More Influential in the Development of Retinopathy of Prematurity: Gram-Positive or Gram-Negative? [PDF]

Children (Basel)
Yeke B, Akin MS, Butun Turk S, Elbayiyev S, Ceran B, Ozdemir O, Cakir U.   +6 more
europepmc   +1 more source

New insights into outer membrane vesicles in Gram-negative bacteria from biogenesis to applications. [PDF]

Commun Biol
Kim B, Son Y, Yang J, Park W.
europepmc   +1 more source

Gram-negative aetiology in hip and knee prosthetic joint infections: risk factors and implications for empirical antibiotic therapy-a retrospective cohort study. [PDF]

JAC Antimicrob Resist
Tedeschi S, Fernandez-Sampedro M, Zamparini E, Rossi N, Ferraro G, Pecorelli A, Fornaro G, Neri MP, Faldini C, Zaffagnini S, De Paolis M, Maso A, Ambretti S, Giannella M, Viale P.   +14 more
europepmc   +1 more source