Results 31 to 40 of about 576,900 (305)
Clinical Infectious Diseases, 2020 BACKGROUND This guidance document provides recommendations to clinicians for the treatment of infections caused by extended-spectrum β-lactamase producing Enterobacterales (ESBL-E), carbapenem-resistant Enterobacterales (CRE), and Pseudomonas aeruginosa ...
P. Tamma +5 more
semanticscholar +1 more source
Plasmid Transfer by Conjugation in Gram-Negative Bacteria: From the Cellular to the Community Level
Genes, 2020 Bacterial conjugation, also referred to as bacterial sex, is a major horizontal gene transfer mechanism through which DNA is transferred from a donor to a recipient bacterium by direct contact.
Chloé Virolle +4 more
semanticscholar +1 more source
Epidemiology and Diagnostics of Carbapenem Resistance in Gram-negative Bacteria
Clinical Infectious Diseases, 2019 Carbapenem resistance in gram-negative bacteria has caused a global epidemic that continues to grow. Although carbapenemase-producing Enterobacteriaceae have received the most attention because resistance was first reported in these pathogens in the ...
P. Nordmann, L. Poirel
semanticscholar +1 more source
A new antibiotic selectively kills Gram-negative pathogens
Nature, 2019 The current need for novel antibiotics is especially acute for drug-resistant Gram-negative pathogens1,2. These microorganisms have a highly restrictive permeability barrier, which limits the penetration of most compounds3,4.
Y. Imai +29 more
semanticscholar +1 more source
Treatment Options for Carbapenem-resistant Gram-negative Bacterial Infections
Clinical Infectious Diseases, 2019 Antimicrobial resistance has become one of the greatest threats to public health, with rising resistance to carbapenems being a particular concern due to the lack of effective and safe alternative treatment options.
Y. Doi
semanticscholar +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Permeability barriers of Gram‐negative pathogens
Annals of the New York Academy of Sciences, 2020 Most clinical antibiotics do not have efficacy against Gram‐negative pathogens, mainly because these cells are protected by the permeability barrier comprising the two membranes with active efflux.
H. Zgurskaya, V. Rybenkov
semanticscholar +1 more source
Extended-spectrum ß-lactamases in gram negative bacteria
Journal of Global Infectious Diseases, 2010 Extended-spectrum ß-lactamases (ESBLs) are a group of plasmid-mediated, diverse, complex and rapidly evolving enzymes that are posing a major therapeutic challenge today in the treatment of hospitalized and community-based patients.
Deepti Rawat, Deepthi Nair
doaj +1 more source