Results 181 to 190 of about 772,298 (352)

Mechanism‐Driven Screening of Membrane‐Targeting and Pore‐Forming Antimicrobial Peptides

Advanced Science, EarlyView.
To combat antibiotic resistance, this study employs mechanism‐driven screening with machine learning to identify pore‐forming antimicrobial peptides from amphibian and human metaproteomes. Seven peptides are validated, showing minimal toxicity and membrane disruption.
Jiaxuan Li, Chenguang Yang, Ruihan Dong, Juan Francisco Bada Juarez, Lei Wang, Maximilian Emanuel Wettstein, Dali Wang, Chan Cao, Ying Lu, Chen Song   +9 more
wiley   +1 more source

Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

Advanced Science, EarlyView.
Time‐restricted feeding (TRF) exerts protein‐dependent neuroprotective effects in an MPTP‐induced Parkinson's disease model. In casein‐fed mice, TRF improves gut barrier integrity and reduces neuroinflammation, possibly via modulation of Allobaculum and BCAAs.
Ting Li, Jian Wu, Sheng‐Yang Zhou, Ming‐An Li, Li‐Ping Zhao, Ao Wang, Yi‐Zhi Song, Wen‐Yan Huang, Lu‐Lu Tan, Chen‐Meng Qiao, Wei‐Jiang Zhao, Chun Cui, Yan‐Qin Shen   +12 more
wiley   +1 more source

Flavonoids: A Review of Antibacterial Activity Against Gram-Negative Bacteria. [PDF]

Int J Microbiol
do Nascimento JB, da Costa JGM.
europepmc   +1 more source

Pharmacodynamic profiling of intravenous antibiotics against gram-negative bacteria collected during the Tracking Resistance in the United States Today (TRUST) surveillance program

, 2010
Pornpan Koomanachai, David P. Nicolau, Joseph L. Kuti, Catharine C. Bulik   +3 more
openalex   +1 more source

Functional Synergy between Antimicrobial Peptoids and Peptides against Gram-Negative Bacteria [PDF]

, 2011
Nathaniel P. Chongsiriwatana, Modi Wetzler, Annelise E. Barron   +2 more
openalex   +1 more source

Efficacy of Colistin with Carbapenems Combination by Checkerboard Assay against Carbapenem Resistant Non Lactose Fermenting Gram Negative Bacteria

, 2023
K. Sreeja Vamsi, Usha Rani Ramavath, B. Rama Chandra Reddy, Mukesh Gandhari, Y. Raja Ratna Reddy   +4 more
openalex   +2 more sources

Iron/Cobalt Dual‐Atom Catalyst Orchestrate Photothermal‐Chemodynamic Immunotherapy Against MRSA: Multi‐Omics Dissection in Murine and Porcine Models

Advanced Science, EarlyView.
FeCo dual‐atom catalyst (FeCo‐N‐DAC) with ultrahigh metal loading (Fe > 5.4%, Co > 4.8%) is developed for synergistic photothermal‐chemodynamic immunotherapy. FeCo‐N‐DAC penetrates deep‐seated tissues, eradicates MRSA biofilms, and reprograms immune‐inflammatory pathways via multi‐omics‐validated mechanisms.
Shihao Xu, Binge Huang, Hao Lin, Jinming Li, Zhaoxiang Lu, Qi Zhang, Jia Li, Shiping Yang, Songsong Lan, Yan Yang, Yun Feng, Xiaojun He   +11 more
wiley   +1 more source

Protein-Protein Interactions as Promising Molecular Targets for Novel Antimicrobials Aimed at Gram-Negative Bacteria. [PDF]

Int J Mol Sci
Maj P, Trylska J.
europepmc   +1 more source

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion

Advanced Science, EarlyView.
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao, Siyuan Chai, Mingyang Li, Xiaoming Chen, Jiating Hu, Bingyi Lin, Liming Wu, Wen Yi, Qiang Zhu   +8 more
wiley   +1 more source

Susceptibility and resistance of Gram-negative bacteria to a novel antimicrobial agent TGV-49. [PDF]

Front Antibiot
Tetz VV, Kardava KM, Vecherkovskaya MF, Leyn SA, Elane ML, Osterman AL, Tetz GV.   +6 more
europepmc   +1 more source