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Niclosamide as a repurposing drug against Gram-positive bacterial infections

Journal of Antimicrobial Chemotherapy, 2022
Abstract Objectives Niclosamide is commonly used as an antiparasitic drug in veterinary clinics. The objectives of this study were to evaluate the efficacy of niclosamide against resistant Gram-positive bacteria in vitro and in an in vivo experimental model of topical bacterial infection. Moreover, to
Wei, Zhang   +8 more
openaire   +2 more sources

Emerging gram-positive bacterial infections

Clinics in Laboratory Medicine, 2004
Over the last several decades, a number of previously known or newly described species of gram-positive bacteria have emerged as important human pathogens, particularly in industrialized countries. These microbes have demonstrated an impressive ability to produce an array of striking infectious diseases never before seen or only infrequently ...
Elsayed, Sameer, Laupland, Kevin B.
openaire   +3 more sources

Gram-positive bacterial infection in severe sepsis

Clinical Intensive Care, 2002
They may be involved in the initial insult precipitating an intensive care admission, but are also often acquired as nosocomial pathogens by critically ill patients. Although sepsis in the context of critical illness is a highly complex process often involving polymicrobial infection, 5-8 discussion of Gr am-po sitive sep sis in isolation is not ...
P Hopkins, S Sriskandan
openaire   +1 more source

Serological detection of Gram-positive bacterial infection around prostheses

The Journal of Bone and Joint Surgery. British volume, 2000
Coagulase-negative staphylococci produce an exocellular glycolipid antigen which has potential as a serological marker of infection in bone. The value of this newly detected antigen was investigated by enzyme-linked immunosorbent assay (ELISA) in 15 patients with culture-proven infection of prostheses caused by Gram-positive bacteria.
M, Rafiq   +6 more
openaire   +2 more sources

Coumarin-modified ruthenium complexes by disrupting bacterial membrane to combat Gram-positive bacterial infection

Dalton Transactions, 2023
Coumarin-modified ruthenium complexes could efficiently disrupt bacterial membrane and cause the death of bacteria.
Hai-Yan Huang   +8 more
openaire   +2 more sources

Teicoplanin- A New Agent for Gram-Positive Bacterial Infections

Infection Control & Hospital Epidemiology, 1988
Gram-positive bacterial infections remain a serious challenge for infectious disease practitioners. Many gram-positive organisms are developing new methods of antibiotic resistance, thus rendering our standard antimicrobial agents ineffective.
M, Eggleston, J, Ofosu
openaire   +2 more sources

Management of gram-positive bacterial infections in patients with cancer

Leukemia & Lymphoma, 2011
Bacterial infections, particularly those due to gram-positive bacteria, continue to predominate in patients with cancer. Coagulase-negative and coagulase-positive staphylococci and enterococci remain as common pathogenic microorganisms. Clostridium difficile has emerged as a significant pathogen.
Kosmidis, Christos I   +1 more
openaire   +3 more sources

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