The spread of multi drug resistant infections is leading to an increase in the empirical antibiotic treatment failure in cirrhosis: a prospective survey [PDF]
, 2015 Background The spread of multi-resistant infections represents a continuously growing problem in cirrhosis,particularly in patients in contact with the healthcare environment.
Ceccarelli, Giancarlo +10 more
core +5 more sources
Journal of Pure and Applied Microbiology, 2022 The gradual rise of multidrug resistant micro-organisms is a national concern for all health care providers. Linezolid belongs to the oxazolidinone class of antimicrobials.
Satish Chandel +3 more
doaj +1 more source
Dynamics of Mycobacterium tuberculosis Ag85B Revealed by a Sensitive Enzyme-Linked Immunosorbent Assay. [PDF]
, 2019 Secretion of specific proteins contributes to pathogenesis and immune responses in tuberculosis and other bacterial infections, yet the kinetics of protein secretion and fate of secreted proteins in vivo are poorly understood. We generated new monoclonal
Bolz, Miriam +2 more
core +2 more sources
Lactoferrin. A natural glycoprotein involved in iron and inflammatory homeostasis [PDF]
, 2017 Human lactoferrin (hLf), an iron-binding multifunctional cationic glycoprotein secreted by exocrine glands and by neutrophils, is a key element of host defenses.
Cutone, Antimo +4 more
core +5 more sources
Potential strategies for the eradication of multi-drug resistant Gram-negative bacterial infections [PDF]
, 2016 Antimicrobial resistance is one of the leading threats to society. The increasing burden of multidrug-resistant Gram-negative infection is particularly concerning as such bacteria are demonstrating resistance to nearly all currently licensed therapies ...
Gilmore, Brendan F. +3 more
core +1 more source
Bacterial pathogens and resistance causing community acquired paediatric bloodstream infections in low- and middle-income countries: a systematic review and meta-analysis [PDF]
, 2019 Background Despite a high mortality rate in childhood, there is limited evidence on the causes and outcomes of paediatric bloodstream infections from low- and middle-income countries (LMICs).
Basmaci, R +5 more
core +2 more sources
Brazilian Journal of Pharmaceutical Sciences, 2020 To evaluate the clinical outcomes of daptomycin therapy and adherence to treatment recommendations, a retrospective cohort study was conducted with patients that received daptomycin during the period of the study.
Tathiana Silva de Souza Martins +5 more
doaj +1 more source
Metabolites, 2023 Lipidomics analyses of bacteria offer the potential to detect and monitor infections in a host since many bacterial lipids are not present in mammals. To evaluate this omics approach, we first built a database of bacterial lipids for representative Gram ...
Paul L. Wood, Erdal Erol
doaj +1 more source
Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections. [PDF]
Antimicrob Agents Chemother, 2017 ABSTRACT Antibiotic-resistant bacteria are widespread and pose a growing threat to human health. New antibiotics acting by novel mechanisms of action are needed to address this challenge. The bacterial methionyl-tRNA synthetase (MetRS) enzyme is essential for protein synthesis, and the type found in Gram-positive bacteria is ...
Faghih O +11 more
europepmc +4 more sources
Vaccines, 2022 Previous reports from our lab have documented dysregulated host inflammatory reactions in response to bacterial infections in sepsis. Both Gram-negative bacteria (GNB) and Gram-positive bacteria (GPB) play a significant role in the development and ...
Ena Gupta +7 more
doaj +1 more source