Results 231 to 240 of about 4,412,822 (263)

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Targeting Gram-Negative Pathogens: drug-design to improve antibiotics permeation

, 2010
Amit Kumar, Matteo Ceccarelli, Paolo Ruggerone, Eric Hajjar   +3 more
core  

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics‐Based Optimization with Limited Activity Data

Advanced Science, EarlyView.
Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley   +1 more source

Endophthalmitis caused by gram-negative bacteria: etiologies, antibiotic susceptibilities, and treatment outcomes. [PDF]

J Ophthalmic Inflamm Infect
Pham B, Zhang C, Sanchez V, Flynn HW, Miller D.   +4 more
europepmc   +1 more source

Novel Fluorinated Chlorhexidine Analogues Overcome Resistance in Gram-Negative Bacteria. [PDF]

ACS Omega
Li Y, Jajja M, Lu J, Chowdhury NS, Hind C, Sutton JM, Rahman KM.   +6 more
europepmc   +1 more source

Which Bacterial Agent Is More Influential in the Development of Retinopathy of Prematurity: Gram-Positive or Gram-Negative? [PDF]

Children (Basel)
Yeke B, Akin MS, Butun Turk S, Elbayiyev S, Ceran B, Ozdemir O, Cakir U.   +6 more
europepmc   +1 more source

Discovery and Optimization of Novel Nonhydroxamate LpxC Inhibitors for the Treatment of Multidrug-Resistant Gram-Negative Infections. [PDF]

J Med Chem
Martin DP, Teng M, Nammalwar B, Perez C, Li X, Munguia J, Taganov K, Fan J, Agarwalla S, Lonergan D, Tomaras AP, Zimmerman Z, Puerta DT.   +12 more
europepmc   +1 more source