Results 101 to 110 of about 119,582 (346)
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
750 GeV diphotons from a D3-brane
Nuclear Physics B, 2016 Motivated by the recently reported diphoton excess at 750 GeV observed by both CMS and ATLAS, we study string-based particle physics models which can accommodate this signal.
Jonathan J. Heckman
doaj +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Georgi-Glashow SU(5) - basis for proton decay and neutrino mass problem from SM to GUT
Journal of Sustainable Technologies and MaterialsIn this article we present the original Georgi-Glashow model with gauge and fermion sector derivation in order to show grand unified theory (GUT) through this model, but also to correlate and Standard Model (SM).
Emina Džaferović-Mašić
doaj +1 more source
Grand unified theories and proton decay
Chinese Science Bulletin, 2018 There exists four fundamental interactions in Nature: strong, weak, hypercharge, and gravity interactions.Based on the conjecture that all the fundamental interactions have the same origin,physicists have explored the Grand Unified Theories,which ...
Tianjun Li
semanticscholar +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Advances in High Energy Physics, 2019 Very recently novel implementation of type-II seesaw mechanism for neutrino mass has been proposed in SU(5) grand unified theory with a number of desirable new physical phenomena beyond the standard model.
M. K. Parida, Rajesh Satpathy
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Flavour symmetries in a renormalizable SO(10) model
Nuclear Physics B, 2016 In the context of a renormalizable supersymmetric SO(10) Grand Unified Theory, we consider the fermion mass matrices generated by the Yukawa couplings to a 10⊕120⊕126‾ representation of scalars. We perform a complete investigation of the possibilities of
P.M. Ferreira +3 more
doaj +1 more source