Results 101 to 110 of about 210,813 (335)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A grand unified theory for the unification of physics, life, information and cognition (mind). [PDF]

Philos Trans A Math Phys Eng Sci, 2023
Swenson R.
europepmc   +1 more source

Non-Commutative GUTs, Standard Model and C,P,T

, 2002
Noncommutative Yang-Mills theories are sensitive to the choice of the representation that enters in the gauge kinetic term. We constrain this ambiguity by considering grand unified theories.
Acampora, Arfaei, Asakawa, B. Jurčo, Banerjee, Barbieri, Bars, Behr, Bichl, Bonora, Bonora, Bonora, Brace, Brace, Calmet, Carlson, Carlson, Chaichian, Chu, Chu, Chu, Connes, Deshpande, Gracia-Bondia, Grimstrup, He, Hewett, Hinchliffe, Hinchliffe, Ho, J. Wess, Jurco, Jurco, Jurco, Jurco, Jurco, Madore, P. Aschieri, P. Schupp, Schupp, Seiberg, Sheikh-Jabbari, Wulkenhaar   +42 more
core   +1 more source

Predictive Dirac and Majorana neutrino mass textures from SU(6) grand unified theories [PDF]

, 2020
Zackaria Chacko, P. S. Bhupal Dev, Rabindra N. Mohapatra, Anil Thapa   +3 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

750 GeV diphotons from a D3-brane

Nuclear Physics B, 2016
Motivated by the recently reported diphoton excess at 750 GeV observed by both CMS and ATLAS, we study string-based particle physics models which can accommodate this signal.
Jonathan J. Heckman
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Georgi-Glashow SU(5) - basis for proton decay and neutrino mass problem from SM to GUT

Journal of Sustainable Technologies and Materials
In this article we present the original Georgi-Glashow  model with gauge and fermion sector derivation in order to show grand unified theory (GUT) through this model, but also to correlate  and Standard Model (SM).
Emina Džaferović-Mašić
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Explaining the SM flavor structure with grand unified theories [PDF]

, 2021
Renato M. Fonseca
openalex   +1 more source