Results 111 to 120 of about 4,875 (298)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A Supersymmetric SO(10) Grand Unified Theory with an Intermediate Symmetry [PDF]
, 2008 http://ptp.ipap.jp/link?PTPS/123/501 | http://ptp.ipap.jp/link?PTPS/123/501We show a concrete construction of a supersymmetric SO(10) Grand Unified Theory with an intermediate symmetry SU(2)_L xotime SU(2)_R xotime SU(3)_C xotime U(1)_.
サトウ, ジョウ, 佐藤, 丈
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Flavour symmetries in a renormalizable SO(10) model
Nuclear Physics B, 2016 In the context of a renormalizable supersymmetric SO(10) Grand Unified Theory, we consider the fermion mass matrices generated by the Yukawa couplings to a 10⊕120⊕126‾ representation of scalars. We perform a complete investigation of the possibilities of
P.M. Ferreira +3 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
, 2006 22 pages, 18 figures, Invited talk given at the 2nd World Summit on Physics Beyond the Standard Model, Galapagos Islands, Ecuador, June 22-25 ...
openaire +2 more sources
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
A “Grand” Unified Negotiation Theory . . . in Context
, 2017 Negotiation research began in the 20th century and is continuing apace. It is pursued from the perspectives of several disciplines including psychology, organizational behavior, labor relations, decision sciences, game theory, communications, legal ...
Schneider, Andrea Kupfer +5 more
core
, 2010 We address the problem of rationalizing the pattern of fermion masses and mixings by adding a non-Abelian flavor symmetry in a grand unified framework. With this purpose, we include an A4 flavor symmetry into a unified renormalizable supersymmetric grand
Ciafaloni P. +3 more
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source