Results 131 to 140 of about 4,875 (298)
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Breakdown of scaling in grand unified theories
, 1981 We investigate the collapse of asymptotic freedom inS U (5) grand unified theory and itsS U (3) c colour subgroup. It is shown that the change from a decreasing to an increasing gauge coupling constant, in the deep Euclidean, is dramatically ...
Morley, P. D., Tucker, Robin
core
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
, 1994 We calculate the two loop contributions to the predictions of the mass scales in an SO(10) grand unified theory. We consider the modified unification scale boundary conditions due to the nonrenormalizable higher dimensional terms arising from quantum ...
Pakvasa, Sandip +2 more
core +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Finite Unification: Theory and Predictions
Symmetry, Integrability and Geometry: Methods and Applications, 2010 All-loop Finite Unified Theories (FUTs) are very interesting N=1 supersymmetric Grand Unified Theories (GUTs) which not only realise an old field theoretic dream but also have a remarkable predictive power due to the required reduction of couplings.
Sven Heinemeyer +2 more
doaj +1 more source
Impaired prohormone processing: a grand unified theory for features of Prader-Willi syndrome? [PDF]
J Clin Invest, 2017 Polex-Wolf J, Yeo GS, O'Rahilly S.
europepmc +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source