Results 161 to 170 of about 259,502 (294)

Adult-born granule cells improve stimulus encoding and discrimination in the dentate gyrus. [PDF]

Elife, 2023
Arribas DM, Marin-Burgin A, Morelli LG.
europepmc   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Tunable High‐Performance Metamaterial Filters Based on Novel SRR Architectures

Advanced Science, EarlyView.
Based on two novel SRR configurations and two independent SRR integration approaches, four tunable bandpass metamaterial filters were fabricated with an ultra‐thin ceramic substrate. Among them, SM‐2 achieves over 97% electromagnetic wave transmittance, with a minimal 1.15% deviation in its resonant frequency prediction, making them promising ...
Lingxi Qu, Liya Zheng, Ruopeng Liu, Chunlin Ji, Bin Li   +4 more
wiley   +1 more source

A dynamic gene regulatory code drives synaptic development of hippocampal granule cells. [PDF]

Sci Adv
Lorente-Echeverría B, Daaboul D, Vandensteen J, Marcassa G, Naert W, Vandenbempt J, Leysen E, Reverendo M, Vlaeminck I, Vervloessem L, Lamote J, Poovathingal S, Davie K, Wierda K, Dascenco D, Aerts S, de Wit J.   +16 more
europepmc   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Adverse gestational environment configures a subpopulation of ventral dentate granule cells for recruitment to drive innate anxiety. [PDF]

Cell Rep
Nabila A, Sciortino R, Politowska N, Brindley E, Hámor PU, Zallar L, Toth JG, Pleil K, Toth M.   +8 more
europepmc   +1 more source

GSK-3β orchestrates the inhibitory innervation of adult-born dentate granule cells in vivo. [PDF]

Cell Mol Life Sci, 2023
Moreno-Jiménez EP, Flor-García M, Hernández-Vivanco A, Terreros-Roncal J, Rodríguez-Moreno CB, Toni N, Méndez P, Llorens-Martín M.   +7 more
europepmc   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

GLP-1 selectively enhances tonic GABA_A receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus. [PDF]

Front Cell Neurosci
Netsyk O, Korol SV, Birnir B, Jin Z.
europepmc   +1 more source

Adult-Generated Dentate Granule Cells in Epilepsy: Loyal Gatekeepers or Evil Changelings? [PDF]

Epilepsy Curr, 2023
Drake AW, Danzer SC.
europepmc   +1 more source