Results 1 to 10 of about 171,910 (118)

Origins, Development, and Compartmentation of the Granule Cells of the Cerebellum

Frontiers in Neural Circuits, 2021
Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the brain: at least 99% of all cerebellar neurons are granule cells.
G. Giacomo Consalez, Daniel Goldowitz, Filippo Casoni, Richard Hawkes   +3 more
doaj   +3 more sources

Single-cell spatial transcriptomic analysis reveals common and divergent features of developing postnatal granule cerebellar cells and medulloblastoma

BMC Biology, 2021
Background Cerebellar neurogenesis involves the generation of large numbers of cerebellar granule neurons (GNs) throughout development of the cerebellum, a process that involves tight regulation of proliferation and differentiation of granule neuron ...
Wenqin Luo, Guan Ning Lin, Weichen Song, Yu Zhang, Huadong Lai, Man Zhang, Juju Miao, Xiaomu Cheng, Yongjie Wang, Wang Li, Wenxiang Wei, Wei-Qiang Gao, Ru Yang, Jia Wang   +13 more
doaj   +1 more source

Inability of granule polarization by NK cells defines tumor resistance and can be overcome by CAR or ADCC mediated targeting

Journal for ImmunoTherapy of Cancer, 2021
Background On encountering a susceptible target, natural killer (NK) cells mediate cytotoxicity through highly regulated steps of directed degranulation.
Torsten Tonn, Winfried Wels, Jiri Eitler, Natalie Wotschel, Nicole Miller, Laurent Boissel, Hans G Klingemann   +6 more
doaj   +1 more source

Spatiotemporal network coding of physiological mossy fiber inputs by the cerebellar granular layer. [PDF]

PLoS Computational Biology, 2017
The granular layer, which mainly consists of granule and Golgi cells, is the first stage of the cerebellar cortex and processes spatiotemporal information transmitted by mossy fiber inputs with a wide variety of firing patterns.
Shyam Kumar Sudhakar, Sungho Hong, Ivan Raikov, Rodrigo Publio, Claus Lang, Thomas Close, Daqing Guo, Mario Negrello, Erik De Schutter   +8 more
doaj   +1 more source

A Sparse, Spatially Biased Subtype of Mature Granule Cell Dominates Recruitment in Hippocampal-Associated Behaviors

Cell Reports, 2020
Summary: Animals can store information about experiences by activating specific neuronal populations, and subsequent reactivation of these neural ensembles can lead to recall of salient experiences.
Sarah R. Erwin, Weinan Sun, Monique Copeland, Sarah Lindo, Nelson Spruston, Mark S. Cembrowski   +5 more
doaj   +1 more source

Hippocampal granule cell dispersion: a non-specific finding in pediatric patients with no history of seizures

Acta Neuropathologica Communications, 2020
Chronic epilepsy has been associated with hippocampal abnormalities like neuronal loss, gliosis and granule cell dispersion. The granule cell layer of a normal human hippocampal dentate gyrus is traditionally regarded as a compact neuron-dense layer ...
Achira Roy, Kathleen J. Millen, Raj P. Kapur   +2 more
doaj   +1 more source

Network pharmacology associated anti-influenza mechanism research of Qingjie-Tuire Granule via STAT1/3 signaling pathway

Heliyon, 2023
Qingjie-Tuire (QT) granule was approved for clinical use and its combination was reported to treat influenza infection. To explore its active component and mechanism, the components of QT granule were retrieved from UPLC-UC-Q-TOF/MS analysis.
Yutao Wang, Xin Zhao, Mengjie Xiao, Xiaoying Lin, Qiaolian Chen, Shengle Qin, Huihui Ti, Zifeng Yang   +7 more
doaj   +1 more source

Generation and characterization of an Nse-CreERT2 transgenic line suitable for inducible gene manipulation in cerebellar granule cells. [PDF]

PLoS ONE, 2014
We created an Nse-CreERT2 mouse line expressing the tamoxifen-inducible CreERT2 recombinase under the control of the neuron-specific enolase (Nse) promoter.
Theresa Pohlkamp, Laura Steller, Petra May, Thomas Günther, Roland Schüle, Michael Frotscher, Joachim Herz, Hans H Bock   +7 more
doaj   +1 more source

The periglomerular cell of the olfactory bulb and its role in controlling mitral cell spiking: a computational model. [PDF]

PLoS ONE, 2013
Interneurons in the olfactory bulb are key elements of odor processing but their roles have not yet being fully understood. Two types of inhibitory interneurons, periglomerular and granule cells, act at two different levels within the olfactory bulb and ...
Denise Arruda, Rodrigo Publio, Antonio C Roque   +2 more
doaj   +1 more source

Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells

Frontiers in Cell and Developmental Biology, 2021
Mast cells are multifunctional immune cells scattered in tissues near blood vessels and mucosal surfaces where they mediate important reactions against parasites and contribute to the pathogenesis of allergic reactions.
Sabrina Sofia Burgener, Sabrina Sofia Burgener, Melanie Brügger, Melanie Brügger, Melanie Brügger, Nathan Georges François Leborgne, Nathan Georges François Leborgne, Sophia Sollberger, Sophia Sollberger, Paola Basilico, Paola Basilico, Thomas Kaufmann, Phillip Ian Bird, Charaf Benarafa, Charaf Benarafa   +14 more
doaj   +1 more source