Results 1 to 10 of about 101,573 (152)

Spatiotemporal network coding of physiological mossy fiber inputs by the cerebellar granular layer. [PDF]

PLoS Computational Biology, 2017
The granular layer, which mainly consists of granule and Golgi cells, is the first stage of the cerebellar cortex and processes spatiotemporal information transmitted by mossy fiber inputs with a wide variety of firing patterns.
Shyam Kumar Sudhakar, Sungho Hong, Ivan Raikov, Rodrigo Publio, Claus Lang, Thomas Close, Daqing Guo, Mario Negrello, Erik De Schutter   +8 more
doaj   +5 more sources

Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics Investigation of Neurodevelopmental Migratory Pathways [PDF]

Frontiers in Cellular Neuroscience, 2020
Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Joan Y. W. Liu, Joan Y. W. Liu, Joan Y. W. Liu, Natasha Dzurova, Batoul Al-Kaaby, Kevin Mills, Sanjay M. Sisodiya, Sanjay M. Sisodiya, Maria Thom, Maria Thom   +9 more
doaj   +3 more sources

The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis

Cell Reports, 2017
The prohormone VGF is expressed in neuroendocrine and endocrine tissues and regulates nutrient and energy status both centrally and peripherally. We and others have shown that VGF-derived peptides have direct action on the islet β cell as secretagogues ...
Samuel B. Stephens, Robert J. Edwards, Masato Sadahiro, Wei-Jye Lin, Cheng Jiang, Stephen R. Salton, Christopher B. Newgard   +6 more
doaj   +3 more sources

A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibition. [PDF]

, 2013
GABAA receptors (GABARs) are the targets of a wide variety of modulatory drugs which enhance chloride flux through GABAR ion channels. Certain GABAR modulators appear to acutely enhance the function of δ subunit-containing GABAR subtypes responsible for ...
Karakossian, Movses H, Meera, Pratap, Otis, Thomas S, Santhakumar, Vijayalakshmi   +3 more
core   +15 more sources

Single-cell spatial transcriptomic analysis reveals common and divergent features of developing postnatal granule cerebellar cells and medulloblastoma

BMC Biology, 2021
Background Cerebellar neurogenesis involves the generation of large numbers of cerebellar granule neurons (GNs) throughout development of the cerebellum, a process that involves tight regulation of proliferation and differentiation of granule neuron ...
Wenqin Luo, Guan Ning Lin, Weichen Song, Yu Zhang, Huadong Lai, Man Zhang, Juju Miao, Xiaomu Cheng, Yongjie Wang, Wang Li, Wenxiang Wei, Wei-Qiang Gao, Ru Yang, Jia Wang   +13 more
doaj   +1 more source

Inability of granule polarization by NK cells defines tumor resistance and can be overcome by CAR or ADCC mediated targeting

Journal for ImmunoTherapy of Cancer, 2021
Background On encountering a susceptible target, natural killer (NK) cells mediate cytotoxicity through highly regulated steps of directed degranulation.
Torsten Tonn, Winfried Wels, Jiri Eitler, Natalie Wotschel, Nicole Miller, Laurent Boissel, Hans G Klingemann   +6 more
doaj   +1 more source

A Sparse, Spatially Biased Subtype of Mature Granule Cell Dominates Recruitment in Hippocampal-Associated Behaviors

Cell Reports, 2020
Summary: Animals can store information about experiences by activating specific neuronal populations, and subsequent reactivation of these neural ensembles can lead to recall of salient experiences.
Sarah R. Erwin, Weinan Sun, Monique Copeland, Sarah Lindo, Nelson Spruston, Mark S. Cembrowski   +5 more
doaj   +1 more source

Hippocampal granule cell dispersion: a non-specific finding in pediatric patients with no history of seizures

Acta Neuropathologica Communications, 2020
Chronic epilepsy has been associated with hippocampal abnormalities like neuronal loss, gliosis and granule cell dispersion. The granule cell layer of a normal human hippocampal dentate gyrus is traditionally regarded as a compact neuron-dense layer ...
Achira Roy, Kathleen J. Millen, Raj P. Kapur   +2 more
doaj   +1 more source

Network pharmacology associated anti-influenza mechanism research of Qingjie-Tuire Granule via STAT1/3 signaling pathway

Heliyon, 2023
Qingjie-Tuire (QT) granule was approved for clinical use and its combination was reported to treat influenza infection. To explore its active component and mechanism, the components of QT granule were retrieved from UPLC-UC-Q-TOF/MS analysis.
Yutao Wang, Xin Zhao, Mengjie Xiao, Xiaoying Lin, Qiaolian Chen, Shengle Qin, Huihui Ti, Zifeng Yang   +7 more
doaj   +1 more source

Generation and characterization of an Nse-CreERT2 transgenic line suitable for inducible gene manipulation in cerebellar granule cells. [PDF]

PLoS ONE, 2014
We created an Nse-CreERT2 mouse line expressing the tamoxifen-inducible CreERT2 recombinase under the control of the neuron-specific enolase (Nse) promoter.
Theresa Pohlkamp, Laura Steller, Petra May, Thomas Günther, Roland Schüle, Michael Frotscher, Joachim Herz, Hans H Bock   +7 more
doaj   +1 more source