Results 41 to 50 of about 5,501,717 (307)

Rab3D is critical for secretory granule maturation in PC12 cells. [PDF]

, 2013
Neuropeptide- and hormone-containing secretory granules (SGs) are synthesized at the trans-Golgi network (TGN) as immature secretory granules (ISGs) and complete their maturation in the F-actin-rich cell cortex.
Sharon A. Tooze (391543), Kögel Tanja, Copier, J., Hodneland, E, Gerdes, HH, Gerdes Hans-Hermann, Tooze, S. A., Tooze Sharon A., Copier, J, Rüdiger Rudolf (151449), Tanja Kögel, Romano Regazzi, Rudolf Rüdiger, Copier John, Gerdes, H. H., Tooze, SA, Tanja Kögel (391540), Kögel, T., Hans-Hermann Gerdes, Kögel, T, Hodneland Erlend, John Copier, Tooze, S.A., Rudolf, R., Regazzi Romano, Regazzi, R, Erlend Hodneland, Gerdes, H.H., Erlend Hodneland (391541), Regazzi, R., Sharon A Tooze, Hodneland, E., John Copier (391542), Rudolf, R, Romano Regazzi (210061), Rüdiger Rudolf, Hans-Hermann Gerdes (127873), Rudolf, Rüdiger, Kögel, Tanja, Regazzi, Romano, Hodneland, Erlend, Copier, John, Gerdes, Hans-Hermann, Tooze, Sharon A.   +43 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Two RNA binding proteins, ADAD2 and RNF17, interact to form a heterogeneous population of novel meiotic germ cell granules with developmentally dependent organelle association.

PLoS Genetics, 2023
Mammalian male germ cell differentiation relies on complex RNA biogenesis events, many of which occur in non-membrane bound organelles termed RNA germ cell granules that are rich in RNA binding proteins (RBPs).
Lauren G Chukrallah, Sarah Potgieter, Lisa Chueh, Elizabeth M Snyder   +3 more
doaj   +1 more source

ATM-deficiency-induced microglial activation promotes neurodegeneration in ataxia-telangiectasia [PDF]

, 2023
While ATM loss of function has long been identified as the genetic cause of ataxia-telangiectasia (A-T), how it leads to selective and progressive degeneration of cerebellar Purkinje and granule neurons remains unclear.
Lai, Jenny, Demirbas, Didem, Tolles, Allie, Lee, Eunjung Alice, Buckley, Patrick G, Jeffries, Ailsa M, Yu, Timothy W, Kim, Junho, Park, Junseok, Chittenden, Thomas W, Lodato, Michael A   +10 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Identification of miRNAs differentially expressed in human epilepsy with or without granule cell pathology.

PLoS ONE, 2014
The microRNAs (miRNAs) are small size non-coding RNAs that regulate expression of target mRNAs at post-transcriptional level. miRNAs differentially expressed under pathological conditions may help identifying mechanisms underlying the disease and may ...
Silvia Zucchini, Gianluca Marucci, Beatrice Paradiso, Giovanni Lanza, Paolo Roncon, Pierangelo Cifelli, Manuela Ferracin, Marco Giulioni, Roberto Michelucci, Guido Rubboli, Michele Simonato   +10 more
doaj   +1 more source

Calcineurin controls the expression of numerous genes in cerebellar granule cells [PDF]

, 2003
The Ca(2+)/calmodulin-dependent phosphatase calcineurin plays a crucial role in gene expression in different cell types such as T-lymphocytes, cardiac myocytes, and smooth muscle cells.
Fresu, Luigia, Ashby, Dominique S, Freeman, Tom C, Genazzani, Armando A, Kramer, Dana   +4 more
core  

GABA-Independent GABAA Receptor Openings Maintain Tonic Currents [PDF]

, 2013
Activation of GABAA receptors (GABAARs) produces two forms of inhibition: ‘phasic’ inhibition generated by the rapid, transient activation of synaptic GABAARs by presynaptic GABA release, and tonic inhibition generated by the persistent activation of ...
Herd, Murray B, Belelli, D., Wlodarczyk, A. I., Sylantyev, S., Linthorst, Astrid C.E., Walker, Matthew C., Walker, M. C., Rusakov, Dmitri A, Lambert, Jeremy J, Wlodarczyk, Agnieszka I., Kersanté, Flavie, Walker, Matthew C, Semyanov, A., Semyanov, Alexey, Rusakov, Dmitri A., Rusakov, D. A., Herd, Murray B., Linthorst, A. C. E., Lambert, Jeremy J., Pavlov, I., Linthorst, Astrid C E, Lambert, J. J., Herd, M. B., Kersante, F., Wlodarczyk, Agnieszka I, Pavlov, Ivan, Sylantyev, Sergiy, Belelli, Delia   +27 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Synaptic representation of locomotion in single cerebellar granule cells

eLife, 2015
The cerebellum plays a crucial role in the regulation of locomotion, but how movement is represented at the synaptic level is not known. Here, we use in vivo patch-clamp recordings to show that locomotion can be directly read out from mossy fiber ...
Kate Powell, Alexandre Mathy, Ian Duguid, Michael Häusser   +3 more
doaj   +1 more source