Results 61 to 70 of about 5,501,717 (307)
Journal of Neuroinflammation, 2011 Background Although the cellular mechanisms responsible for the pathogenesis of autism are not understood, a growing number of studies have suggested that localized inflammation of the central nervous system (CNS) may contribute to the development of ...
Dobkin Carl +6 more
doaj +1 more source
Deletion of Mea6 in Cerebellar Granule Cells Impairs Synaptic Development and Motor Performance
Frontiers in Cell and Developmental Biology, 2021 The cerebellum is conceptualized as a processor of complex movements. Many diseases with gene-targeted mutations, including Fahr’s disease associated with the loss-of-function mutation of meningioma expressed antigen 6 (Mea6), exhibit cerebellar ...
Xin-Tai Wang +7 more
doaj +1 more source
Monensin induces secretory granule-mediated cell death in eosinophils
, 2023 Background: Eosinophils contribute to the pathology of several types of disorders, in particular of allergic nature, and strategies to limit their actions are therefore warranted.
Mirjana Grujic +20 more
core +1 more source
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis
Cell Reports, 2017 The prohormone VGF is expressed in neuroendocrine and endocrine tissues and regulates nutrient and energy status both centrally and peripherally. We and others have shown that VGF-derived peptides have direct action on the islet β cell as secretagogues ...
Samuel B. Stephens +6 more
doaj +1 more source
The RacGAP βChimaerin is essential for cerebellar granule cell migration
, 2017 During mammalian cerebellar development, postnatal granule cell progenitors proliferate in the outer part of the External Granule Layer (EGL). Postmitotic granule progenitors migrate tangentially in the inner EGL before switching to migrate radially ...
Yiu-Cheung E. Wong +4 more
core +1 more source
The RacGAP β-Chimaerin is essential for cerebellar granule cell migration [PDF]
, 2018 During mammalian cerebellar development, postnatal granule cell progenitors proliferate in the outer part of the External Granule Layer (EGL). Postmitotic granule progenitors migrate tangentially in the inner EGL before switching to migrate radially ...
Estep, Jason A +9 more
core +1 more source
Algorithm 1: Single front growth and Algorithm 2: Manage granule cell fronts.
, 2023 Algorithm 1: Single front growth and Algorithm 2: Manage granule cell fronts.
Erik De Schutter (29220) +1 more
core +1 more source
FEBS Open Bio, EarlyView.We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen +5 more
wiley +1 more source
eLife, 2018 Alternative polyadenylation (APA) regulates mRNA translation, stability, and protein localization. However, it is unclear to what extent APA regulates these processes uniquely in specific cell types.
Saša Jereb +7 more
doaj +1 more source