Results 71 to 80 of about 178,493 (310)

Acidic pH is essential for maintaining mast cell secretory granule homeostasis

, 2017
It has been recognized for a long time that the secretory granules of mast cells are acidic, but the functional importance of maintaining an acidic pH in the mast cell granules is not fully understood.
Sjöström, Daniel, Jun Mei Hu Frisk, Daniel Sjöström, Sveriges lantbruksuniversitet., Pejler, Gunnar,, Helena Öhrvik, Frisk, Jun Mei Hu,, Paivandy, Aida, Öhrvik, Helena, Pejler, Gunnar, Öhrvik, Helena,, Aida Paivandy, Frisk, Jun Mei Hu, Gunnar Pejler, Paivandy, Aida,   +14 more
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Deletion of Mea6 in Cerebellar Granule Cells Impairs Synaptic Development and Motor Performance

Frontiers in Cell and Developmental Biology, 2021
The cerebellum is conceptualized as a processor of complex movements. Many diseases with gene-targeted mutations, including Fahr’s disease associated with the loss-of-function mutation of meningioma expressed antigen 6 (Mea6), exhibit cerebellar ...
Xin-Tai Wang, Lin Zhou, Lin Zhou, Xin-Yu Cai, Fang-Xiao Xu, Zhi-Heng Xu, Xiang-Yao Li, Ying Shen   +7 more
doaj   +1 more source

Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

, 2018
Glucose-stimulated insulin secretion is biphasic, with a rapid first phase and a slowly developing sustained second phase; both are disturbed in type 2 diabetes (T2D).
Sebastian Barg, Emilia Ottosson Laakso, Vikman, Petter, Omar-Hmeadi, Muhmmad, Nikhil R. Gandasi, Vikman, Petter,, Peng Yin, Yin, Peng, Gandasi, Nikhil R,, Gandasi, Nikhil R., Yin, Peng,, Muhmmad Omar-Hmeadi, Omar-Hmeadi, Muhmmad,, Ottosson Laakso, Emilia,, Barg, Sebastian, Petter Vikman, Barg, Sebastian,, Ottosson Laakso, Emilia   +17 more
core   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

A role for Bicaudal-D2 in radial cerebellar granule cell migration

, 2014
Bicaudal-D (BICD) belongs to an evolutionary conserved family of dynein adaptor proteins. It was first described in Drosophila as an essential factor in fly oogenesis and embryogenesis.
Wulf, Phebe S., Celbiologie, de Zeeuw, Chris, Hoogenraad, Casper C, Pasterkamp, RJ, Schlager, Max A, van Erp, Susan, van Erp, S, Graaff, Esther, Wulf, Phebe S, De Zeeuw, Chris I, Wulf, PS, Pasterkamp, R Jeroen, Hoogenraad, CC, Sub Cell Biology, Pasterkamp, R. Jeroen, Berg, Robert, Akhmanova, Anna, Schlager, Max, van den Berg, Robert, Jaarsma, Dick, Keijzer, Nanda, de Graaff, Esther   +22 more
core   +1 more source

Powder Optimization Strategies for Binder Jetting Printing of BaTiO3 and Ba0,6Sr0,4TiO3 Ceramics

Advanced Engineering Materials, EarlyView.
Powder optimization is investigated to enable binder jetting of BaTiO3 and Ba0.6Sr0.4TiO3 ferroelectric ceramics. The antagonistic relationship between flowability and binder compatibility is addressed through binder impregnation of granulated powders and fumed silica addition to fine powders.
Fanny Pruvost, Lionel Presmanes, Soléna Colin, Marie Vidal, Sophie Guillemet‐Fritsch   +4 more
wiley   +1 more source

Differential 3’ processing of specific transcripts expands regulatory and protein diversity across neuronal cell types

eLife, 2018
Alternative polyadenylation (APA) regulates mRNA translation, stability, and protein localization. However, it is unclear to what extent APA regulates these processes uniquely in specific cell types.
Saša Jereb, Hun-Way Hwang, Eric Van Otterloo, Eve-Ellen Govek, John J Fak, Yuan Yuan, Mary E Hatten, Robert B Darnell   +7 more
doaj   +1 more source

Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases

, 1997
Activation of ICE/Ced-3 family proteases (caspases) has been proposed to mediate both the granule exocytosis and Fas–Fas ligand pathways of rapid target cell death by cytotoxic T lymphocytes.
Alexander-Miller, Martha A., Berzofsky, Jay A., Zacharchuk, Charles M., Sarin, Apurva, Henkart, Pierre A., Williams, Mark S.   +5 more
core   +1 more source

Incorporation of Selenium into Sol–Gel‐Derived Bioactive Glass: Influence on Glass Structure, Bioactivity, and its Selective Cytotoxicity

Advanced Engineering Materials, EarlyView.
Selenium was incorporated into a sol–gel‐derived bioactive glass to enable sustained therapeutic ion release. The selenium‐containing glass preserved bioactivity while selectively inducing cytotoxicity in osteosarcoma cells and maintaining osteoblastic viability.
Breno Rocha Barrioni, Thalita Marcolan Valverde, Talita Martins, Guilherme Mattos Jardim Costa, Alfredo Miranda de Goes, Marcello Rosa Dumont, Eduardo Henrique Martins Nunes, Marivalda de Magalhães Pereira   +7 more
wiley   +1 more source