Results 11 to 20 of about 178,493 (310)

Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells [PDF]

Frontiers in Cell and Developmental Biology, 2021
Mast cells are multifunctional immune cells scattered in tissues near blood vessels and mucosal surfaces where they mediate important reactions against parasites and contribute to the pathogenesis of allergic reactions.
Sabrina Sofia Burgener, Sabrina Sofia Burgener, Melanie Brügger, Melanie Brügger, Melanie Brügger, Nathan Georges François Leborgne, Nathan Georges François Leborgne, Sophia Sollberger, Sophia Sollberger, Paola Basilico, Paola Basilico, Thomas Kaufmann, Phillip Ian Bird, Charaf Benarafa, Charaf Benarafa   +14 more
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Hilar mossy cell circuitry controlling dentate granule cell excitability

Frontiers in Neural Circuits, 2013
Glutamatergic hilar mossy cells of the dentate gyrus can either excite or inhibit distant granule cells, depending on whether their direct excitatory projections to granule cells or their projections to local inhibitory interneurons dominate. However, it
Seiichiro eJinde, Veronika eZsiros, Kazu eNakazawa   +2 more
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Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics Investigation of Neurodevelopmental Migratory Pathways [PDF]

Frontiers in Cellular Neuroscience, 2020
Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Joan Y. W. Liu, Joan Y. W. Liu, Joan Y. W. Liu, Natasha Dzurova, Batoul Al-Kaaby, Kevin Mills, Sanjay M. Sisodiya, Sanjay M. Sisodiya, Maria Thom, Maria Thom   +9 more
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The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis

Cell Reports, 2017
The prohormone VGF is expressed in neuroendocrine and endocrine tissues and regulates nutrient and energy status both centrally and peripherally. We and others have shown that VGF-derived peptides have direct action on the islet β cell as secretagogues ...
Samuel B. Stephens, Robert J. Edwards, Masato Sadahiro, Wei-Jye Lin, Cheng Jiang, Stephen R. Salton, Christopher B. Newgard   +6 more
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Single-cell spatial transcriptomic analysis reveals common and divergent features of developing postnatal granule cerebellar cells and medulloblastoma

BMC Biology, 2021
Background Cerebellar neurogenesis involves the generation of large numbers of cerebellar granule neurons (GNs) throughout development of the cerebellum, a process that involves tight regulation of proliferation and differentiation of granule neuron ...
Wenqin Luo, Guan Ning Lin, Weichen Song, Yu Zhang, Huadong Lai, Man Zhang, Juju Miao, Xiaomu Cheng, Yongjie Wang, Wang Li, Wenxiang Wei, Wei-Qiang Gao, Ru Yang, Jia Wang   +13 more
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Inability of granule polarization by NK cells defines tumor resistance and can be overcome by CAR or ADCC mediated targeting

Journal for ImmunoTherapy of Cancer, 2021
Background On encountering a susceptible target, natural killer (NK) cells mediate cytotoxicity through highly regulated steps of directed degranulation.
Torsten Tonn, Winfried Wels, Jiri Eitler, Natalie Wotschel, Nicole Miller, Laurent Boissel, Hans G Klingemann   +6 more
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Spatiotemporal network coding of physiological mossy fiber inputs by the cerebellar granular layer. [PDF]

PLoS Computational Biology, 2017
The granular layer, which mainly consists of granule and Golgi cells, is the first stage of the cerebellar cortex and processes spatiotemporal information transmitted by mossy fiber inputs with a wide variety of firing patterns.
Shyam Kumar Sudhakar, Sungho Hong, Ivan Raikov, Rodrigo Publio, Claus Lang, Thomas Close, Daqing Guo, Mario Negrello, Erik De Schutter   +8 more
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A Sparse, Spatially Biased Subtype of Mature Granule Cell Dominates Recruitment in Hippocampal-Associated Behaviors

Cell Reports, 2020
Summary: Animals can store information about experiences by activating specific neuronal populations, and subsequent reactivation of these neural ensembles can lead to recall of salient experiences.
Sarah R. Erwin, Weinan Sun, Monique Copeland, Sarah Lindo, Nelson Spruston, Mark S. Cembrowski   +5 more
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Hippocampal granule cell dispersion: a non-specific finding in pediatric patients with no history of seizures

Acta Neuropathologica Communications, 2020
Chronic epilepsy has been associated with hippocampal abnormalities like neuronal loss, gliosis and granule cell dispersion. The granule cell layer of a normal human hippocampal dentate gyrus is traditionally regarded as a compact neuron-dense layer ...
Achira Roy, Kathleen J. Millen, Raj P. Kapur   +2 more
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Network pharmacology associated anti-influenza mechanism research of Qingjie-Tuire Granule via STAT1/3 signaling pathway

Heliyon, 2023
Qingjie-Tuire (QT) granule was approved for clinical use and its combination was reported to treat influenza infection. To explore its active component and mechanism, the components of QT granule were retrieved from UPLC-UC-Q-TOF/MS analysis.
Yutao Wang, Xin Zhao, Mengjie Xiao, Xiaoying Lin, Qiaolian Chen, Shengle Qin, Huihui Ti, Zifeng Yang   +7 more
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