Results 251 to 260 of about 73,182 (298)
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Granulocyte macrophage colony-stimulating factor in adenomyosis and autologous endometrium
Journal of the Society for Gynecologic Investigation, 2002Granulocyte macrophage colony-stimulating factor (GM-CSF) has been related to macrophage recruitment and activation and has been identified in the human endometrium. We determined whether adenomyosis expresses GM-CSF, and if present, compared GM-CSF protein expression in adenomyosis with that in autologous endometrium.We examined ectopic and eutopic ...
Elizabeth A. Stewart +3 more
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European Journal of Cancer, 1994
The purpose of this communication was to explore which situations in radiotherapy might benefit from concomitant administration of haematopoietic growth factors (HGF). Only large-field radiotherapy is likely to induce bone marrow depression, such as irradiation of Hodgkin's disease.
Janssens, P. +3 more
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The purpose of this communication was to explore which situations in radiotherapy might benefit from concomitant administration of haematopoietic growth factors (HGF). Only large-field radiotherapy is likely to induce bone marrow depression, such as irradiation of Hodgkin's disease.
Janssens, P. +3 more
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Granulocyte-macrophage colony-stimulating factor and the immune system
Medical Oncology, 1996Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifunctional cytokine currently used for the reversal of neutropenia associated with cytotoxic chemotherapy, bone marrow and haemopoietic stem cell transplantation. GM-CSF also modulates the function of differentiated white blood cells.
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Lowering Cholesterol With Granulocyte-Macrophage Colony-Stimulating Factor
JAMA: The Journal of the American Medical Association, 1989To the Editor.— We read with interest the report by Nimer and coworkers 1 demonstrating that granulocyte-macrophage colony-stimulating factor (GM-CSF) lowers serum cholesterol when administered by infusion to patients with aplastic anemia. The authors postulate a number of potential mechanisms whereby GM-CSF may alter cholesterol metabolism.
Peter Herbert, Eric M. Mazur
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Involvement of Granulocyte-Macrophage Colony-Stimulating Factor in Pulmonary Homeostasis
Science, 1994The in vivo function of murine granulocyte-macrophage colony-stimulating factor (GM-CSF) was investigated in mice, carrying a null allele of the GM-CSF gene, that were generated by gene targeting techniques in embryonic stem cells. Although steady-state hematopoiesis was unimpaired in homozygous mutant animals, all animals developed the progressive ...
Roderick T. Bronson +10 more
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Emerging paradigms in granulocyte-macrophage colony-stimulating factor signaling
Life Sciences, 1996The myelomonocytic lineage of hematopoiesis is regulated by the growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF). This cytokine has proven to be safe for use in coordination with the treatments for bone marrow transplants and acute myelogenous leukemia.
Christina Veatch +1 more
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cDNA cloning of porcine granulocyte‐macrophage colony‐stimulating factor
Immunology & Cell Biology, 1995SummaryPorcine granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) cDNA was cloned by using polymerase chain reaction (PCR) and sequenced. A coding sequence of the porcine GM‐CSF precursor protein, including the signal peptide sequence and stop codon, is 435 bp in length. The identities of the porcine GM‐CSF coding sequence when compared to ovine,
H Takamatsu, S Inumaru
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Molecular Structure and Granulocyte/Macrophage Colony-Stimulating Factor Activity
DNA and Cell Biology, 1992Granulocyte/macrophage colony-stimulating factor (GM-CSF) plays a critical role in myeloid differentiation and in several immune and inflammatory processes. GM-CSF binds to specific cellular receptors (GM-CSFR) which belong to a recently described supergene family.
Joan M. Von Feldt +4 more
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Granulocyte-macrophage colony-stimulating factor mimicry and receptor interactions
Immunologic Research, 1994Development of small molecular mimics of larger polypeptide ligands is an important approach to pharmacophore design. One strategy for the development of such mimics is analysis of alternative ligands that bind to the same site as the native ligand. These allow examination of the structural and chemical constraints for binding within the setting of ...
Cristina Monfardini +6 more
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[43] Murine granulocyte-macrophage colony-stimulating factor
1985Publisher Summary This chapter discusses the murine granulocyte-macrophage colony-stimulating factor. The differentiation and proliferation of hemopoietic progenitor cells is highlighted, that it is dependent on a set of specific glycoproteins. One of these glycoproteins is granulocyte-macrophage colony-stimulating factor (GM-CSF), which stimulates ...
Edouard C. Nice, Antony W. Burgess
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