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Current Understanding of the Neutrophil Transcriptome in Health and Disease

Cells, 2021
Neutrophils are key cells of the innate immune system. It is now understood that this leukocyte population is diverse in both the basal composition and functional plasticity.
Luke W. Garratt
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Distinct phenotype of neutrophil, monocyte, and eosinophil populations indicates altered myelopoiesis in a subset of patients with multiple myeloma

Frontiers in Oncology, 2023
Hematologic malignancies, including multiple myeloma (MM), promote systemic immune dysregulation resulting in an alteration and increased plasticity of myeloid cell subsets. To determine the heterogeneity of the myeloid cell compartment in the peripheral
Krystle L. Ong, Marcus D. Davis, Kalyn K. Purnell, Hannah Cutshall, Harish C. Pal, Ashley N. Connelly, Christian X. Fay, Valeriya Kuznetsova, Elizabeth E. Brown, Elizabeth E. Brown, Zdenek Hel, Zdenek Hel, Zdenek Hel   +12 more
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Neutrophil Functional Heterogeneity: Identification of Competitive Phagocytosis

Frontiers in Immunology, 2017
IntroductionPhagocytosis by neutrophils is a key process in the innate immune response against invading microorganisms. Despite reported heterogeneity in other neutrophils functions, little is known regarding differences in phagocytosis by individual ...
Pien Hellebrekers, Pien Hellebrekers, Falco Hietbrink, Nienke Vrisekoop, Luke P. H. Leenen, Leo Koenderman   +5 more
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Increased CD11b and Decreased CD62L in Blood and Airway Neutrophils from Long-Term Smokers with and without COPD

Journal of Innate Immunity, 2020
There is incomplete mechanistic understanding of the mobilization of neutrophils in the systemic and local compartment in smokers with chronic obstructive pulmonary disease (COPD).
Marit Stockfelt, Karin Christenson, Anders Andersson, Lena Björkman, Médea Padra, Bettina Brundin, Koustav Ganguly, Helga Asgeirsdottir, Sara Lindén, Ingemar Qvarfordt, Johan Bylund, Anders Lindén   +11 more
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Surgical manipulation compromises leukocyte mobilisation responses and inflammation after experimental cerebral ischaemia in mice

Frontiers in Neuroscience, 2014
Acute brain injury results in peripheral inflammatory changes, although the impact of these processes on neuronal death and neuroinflammation is currently unclear.
Adam eDenes, Adam eDenes, JESUS MIGUEL PRADILLO, Caroline eDrake, Hannah eBuggey, Nancy J Rothwell, Stuart M Allan   +6 more
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The lasting influence of LSD1 in the blood

eLife, 2013
An enzyme called LSD1 that controls the development of blood cells by manipulating gene expression in progenitor cells could be a therapeutic target for leukemia.
Sharon YR Dent, Joya Chandra
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Secretory Leukocyte Protease Inhibitor Is Present in Circulating and Tissue-Recruited Human Eosinophils and Regulates Their Migratory Function

Frontiers in Immunology, 2022
Eosinophils and secretory leukocyte protease inhibitor (SLPI) are both associated with Th2 immune responses and allergic diseases, but whether the fact that they are both implicated in these conditions is pathophysiologically related remains unknown ...
Oktawia Osiecka, Joanna Skrzeczynska-Moncznik, Agnieszka Morytko, Angelika Mazur, Pawel Majewski, Bernadetta Bilska, Monika Kapinska-Mrowiecka, Joanna Kosalka-Wegiel, Joanna Kosalka-Wegiel, Maciej Pastuszczak, Elzbieta Pyza, Joanna Cichy   +11 more
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Porphyromonas gingivalis Produce Neutrophil Specific Chemoattractants Including Short Chain Fatty Acids

Frontiers in Cellular and Infection Microbiology, 2021
Neutrophil migration from blood to tissue-residing microbes is governed by a series of chemoattractant gradients of both endogenous and microbial origin. Periodontal disease is characterized by neutrophil accumulation in the gingival pocket, recruited by
Agnes Dahlstrand Rudin, Arsham Khamzeh, Vignesh Venkatakrishnan, Tishana Persson, Michael Gabl, Otto Savolainen, Huamei Forsman, Claes Dahlgren, Karin Christenson, Johan Bylund   +9 more
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Dendritic Cell Activating Receptor 1 (DCAR1) Associates With FcεRIγ and Is Expressed by Myeloid Cell Subsets in the Rat

Frontiers in Immunology, 2019
Dendritic cell activating receptor-1 (DCAR1) is a cell-surface receptor encoded by the Antigen Presenting Lectin-like gene Complex (APLEC). We generated a mouse monoclonal antibody against rat DCAR1, and used this to characterize receptor expression and ...
Michael R. Daws, Britt Nakken, Ana Lobato-Pascual, Régis Josien, Régis Josien, Erik Dissen, Sigbjørn Fossum   +6 more
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Review: Relationships between metabolism and neutrophil function in dairy cows in the peripartum period

Animal, 2020
Aspects of neutrophil function are diminished or dysregulated in dairy cows in the weeks just before and after calving, which appears to be an important contributor to the occurrence of retained placenta, mastitis, metritis and endometritis.
S.J. LeBlanc
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