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Circular Permutation of Granulocyte Colony-Stimulating Factor
Biochemistry, 1999The sequence of granulocyte colony-stimulating factor (G-CSF) has been circularly permuted by introducing new chain termini into interhelical loops and by constraining the N- and C-terminal helices, either by direct linkage of the termini (L0) or by substitution of the amino-terminal 10-residue segment with a seven-residue linker composed of glycines ...
Linda L. Zurfluh +10 more
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Current Opinion in Hematology, 1997
The hematopoietic growth factors granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) not only regulate the numbers of circulating neutrophils but also modulate the function of mature cells. Additionally, newly developed neutrophils subsequently released from the bone marrow in response to colony ...
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The hematopoietic growth factors granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) not only regulate the numbers of circulating neutrophils but also modulate the function of mature cells. Additionally, newly developed neutrophils subsequently released from the bone marrow in response to colony ...
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Granulocyte-Macrophage Colony-Stimulating Factor in Psoriasis
Dermatology, 1990Granulocyte-macrophage colony-stimulating factor (GM-CSF), a product of activated T lymphocytes, macrophages, endothelial cells, fibroblasts, and keratinocytes, is thought to play an important role in inflammatory reactions by ‘priming’ or enhancing the functions of neutrophils and macrophages.
H. Takematsu, Hachiro Tagami
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Functions of Granulocyte-Macrophage Colony-Stimulating Factor
Critical Reviews in Immunology, 2005GM-CSF was originally defined by its ability to generate in vitro granulocyte and macrophage colonies from bone marrow precursor cells. Apart from its physiological role in the control of alveolar macrophage development, it now appears more likely that its major role lies in its ability to govern the properties of the more mature myeloid cells of the ...
Andrew J. Fleetwood +2 more
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Effect of Colony-Stimulating Factors on Granulocyte Function
1993Phagocytes including polymorphonuclear neutrophils (PMN), monocytes, macrophages, and eosinophils are essential for host defense against certain microbes and probably play an important role in the surveillance and destruction of neoplastic cells. The production, maturation, and function of these cells appear to be regulated in a very complex manner by ...
K. Vollmer, G. L. Mandell
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Clinical applications of granulocyte-colony stimulating factor
Frontiers in Bioscience, 2007Granulocyte colony stimulating factor (G-CSF) is a naturally occurring potent neutrophil growth factor. Recombinant human G-CSF has been developed by pharmaceutical companies, and since the late 1980's, multiple clinical trials have explored its efficacy in a variety of medical conditions.
Lillian Sung, Yigal Dror
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Mutagenesis of human granulocyte colony stimulating factor
Biochemical and Biophysical Research Communications, 1989To define the structure-function relationship, we have made a number of mutants of human granulocyte colony-stimulating factor (hG-CSF) by in vitro mutagenesis. The results indicate that most of the mutations located in the internal and C-terminal regions of the molecule abolished the activity, whereas the mutants without N-terminal 4, 5, 7, or 11 ...
Seiga Itoh +11 more
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Impurities in Granulocyte Colony-Stimulating Factor?
Archives of Dermatology, 1994The case presented by Samlaska and Noyes 1 in the May 1993 issue of theArchivesof a patient who developed pruritus and erythematous edematous plaques at granulocyte colony-stimulating factor (G-CSF) injection sites is very interesting and unique with regard to the authors' conjecture at possible causation.
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Neuroprotective Effect of Granulocyte-Colony Stimulating Factor
Frontiers in Bioscience, 2007Granulocyte-colony stimulating factor (G-CSF) is a growth factor which stimulates proliferation, differentiation, and survival of hematopoietic progenitor cells. G-CSF is being used extensively in clinical practice to accelerate recovery of patients from neutropenia after cytotoxic therapy.
Jadhav, John H. Zhang, Ihsan Solaroglu
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The Granulocyte-Macrophage Colony-Stimulating Factors [PDF]
, 1986 Haemopoiesis is the process whereby a small population of multipotential stem cells continuously gives rise to a large number of mature blood cells which comprise eight distinct cellular lineages. In normal health, the circulating levels of mature cells are remarkably invariant, suggesting that their production is tightly regulated.
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