Results 91 to 100 of about 114,052 (250)

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

The influence of smoking on the formation of airway hyperresponsiveness to cold and the course of destructive-cytological processes in the goblet cells of the bronchial epithelium in patients with asthma

Бюллетень сибирской медицины, 2019
Tobacco smoking in patients with asthma can intensify the bronchi mucosa damage and significantly worsen the course of the disease.Aim. To assess the influence of tobacco smoking on the clinical manifestations of the disease, airway response to cold air ...
A. B. Pirogov, A. G. Prikhodko, V. P. Kolosov, Ju. M. Perelman   +3 more
doaj   +1 more source

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

Advanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler   +13 more
wiley   +1 more source

Interaction of microglia and neutrophil granulocytes 24 h after photothrombosis.

, 2018
A The panel demonstrates a direct physical contact which is reconstructed and displayed in different angles in A´. The time series in B show the reaction of a microglia on a passing neutrophil granulocytes by extension of the protrusions towards the ...
Klaus G. Reymann (54217), Niklas Nolte (4966633), Andreas J. Müller (211842), Burkhart Schraven (34080), Matthias Gunzer (41171), Sophie Henneberg (4966630), Susanne von Kenne (4966624), Michael W. Görtler (4966627), Monika Riek-Burchardt (229302), Jens Neumann (4966621)   +9 more
core   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Analysis of miR-125b function in granulocytes under steady phase.

, 2018
(a) Chemotaxis of BM-derived granulocytes. Total bone marrow cells were harvested from BM chimeras 8 to 10 weeks post-transplantation. Granulocytes (> 90%) were enriched by using Percoll gradient cell separation.
Matthias Eder (21135), Arnold Ganser (4454), Denise Hilfiker-Kleiner (224409), Karin Battmer (565374), Chun-Wei Lee (321042), Michaela Scherr (21136), Caroline Schoenherr (5819627), Sascha David (319986)   +7 more
core   +1 more source

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

Inhibition of platelet aggregation by granulocytes stimulated during experimental trauma

, 1990
The effect of granulocytes, stimulated in vivo by standardized soft tissue trauma, on the aggregation of autologous platelets in vitro, was studied in the pig.
Thorne, J., Thorne, J.,, Faldt, R., Faldt, R.,, Zoucas, E.,, Ankerst, J.,, Lund University., Zoucas, E., Ankerst, J.   +8 more
core   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source