Results 191 to 200 of about 106,660 (298)

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, EarlyView.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

Cytokine-driven modulation of peripheral immune cell populations in Coronavirus disease 2019 patients. [PDF]

Front Immunol
Choto TA, Ndlovu B, Naicker T, Mduluza T.   +3 more
europepmc   +1 more source

Predictive Biomarkers in Metastatic Colorectal Cancer Patients Treated With Bevacizumab: A Turkish Oncology Group (TOG) Study

International Journal of Cancer, EarlyView.
Bevacizumab added to systemic chemotherapy remains a cornerstone of metastatic colorectal cancer treatment, but its effectiveness is variable. Tumors can bypass the VEGF blockade by activating other pro‐angiogenic pathways, hampering the identification of predictive biomarkers.
Büsra Akay Hacan, Fatma Gizem Sonugür, Müge Öçal, Cansu Babahan, Samira Abgarmi, Ülkü Yalçıntaş Arslan, Mehmet Ali Şendur, Ahmet Demirkazık, Güngör Utkan, Hakan Akbulut   +9 more
wiley   +1 more source

VEGFR Blockade Reduces <i>Mycobacterium tuberculosis</i>-Induced Lung Pathology in Immunocompromised Mice. [PDF]

Cells
Herbath M, Harding J, Priyathilaka TT, Laaker CJ, Kafkas A, Fabry Z, Sandor M.   +6 more
europepmc   +1 more source

Total Neoadjuvant Treatment for Esophageal Adenocarcinoma With Oligometastases: TNT‐OES‐1 Trial

International Journal of Cancer, EarlyView.
Total neoadjuvant therapy could combine the potentially strong systemic effect of FLOT chemotherapy with the good locoregional control of CROSS chemoradiotherapy. While total neoadjuvant therapy is increasingly used in rectal cancer, its potential in gastroesophageal cancer remains largely unexplored.
Charlène J. van der Zijden, Tamara J. Huizer, Ben M. Eyck, Ate van der Gaast, Leni van Doorn, Marjolein Y. V. Homs, J. Jan B. van Lanschot, Joost J. M. E. Nuyttens, Lindsey Oudijk, Manon C. W. Spaander, Bas P. L. Wijnhoven, Bianca Mostert, Sjoerd M. Lagarde   +12 more
wiley   +1 more source

Integrated single-cell transcriptomic analysis identifies <i>PF4</i> ^<i>+</i> <i>/PPBP</i> ^<i>+</i> megakaryocyte-like granulocytes associated with immune dysregulation in autoimmune diseases. [PDF]

Biochem Biophys Rep
Chen S, Fan Y, Su M, Lin Y, Zheng S, Zhou Z, Zhang W, Lin J, Hu S, Matucci-Cerinic M, Furst DE, Zhang G, Wang Y.   +12 more
europepmc   +1 more source

The role of human microbiota in breast cancer pathogenesis and treatment

iMeta, EarlyView.
The human microbiota contributes to breast cancer pathogenesis and treatment response through interactions involving the oral, gut, and breast microbial niches. (Left) Multi‐site dysbiosis is characterized by altered microbial composition and abundance across different anatomical sites.
Jie Qiu, Xiaojia Wang, Man Li, Jing Guo, Shipeng Ning, Yi‐Zhou Gao, Xinyi Zhang, Xuli Meng, Yiding Chen, Yunxiang Zhou   +9 more
wiley   +1 more source

Telomere attrition is common in patients with germline <i>RUNX1</i> pathogenic variants. [PDF]

Haematologica
Lawal RA, Gutierrez-Rodrigues F, Young DJ, Bresciani E, Groarke EM, Deuitch NT, McGuinness M, Craft K, Chong S, Sierk M, Meerzaman D, Patel BA, Young NS, Weng NP, Liu PP.   +14 more
europepmc   +1 more source

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

Interdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu, Jieyun Xu, Yuan Zhao, Xinyu Guo, Hongcheng Chen, Junlong Xue, Yong Ao, Linjun Zhang, Xiaomeng Gao, Xueli Mao, Songtao Shi, Zetao Chen   +11 more
wiley   +1 more source

The cellular response capacity (CRC) as a novel immunomonitoring approach in sepsis. [PDF]

Mil Med Res
Messerer DAC, Müller P, Wohlgemuth L, Münnich F, Stukan L, Mohamed AOK, Hagemann JB, Koller AS, Jovanovski D, Lauer S, Traut R, Schöbel L, Thomaß BD, Münnich F, Barth E, Weiss M, Liebold A, Jungwirth B, Huber-Lang M.   +18 more
europepmc   +1 more source