Results 51 to 60 of about 196,918 (257)

Changes in the exposure of CD11b on the surface of granulocytes, after activation of Toll-like receptors in children with recurrent infections

Біологічні студії, 2016
The effect of activation of Toll-like receptors (TLR) on presentation of CD11b adhesion molecule at the granulocytes surface in children of different age with recurrent infections was investigated.
D. V. Osypchuk, O. V. Rabosh
doaj   +1 more source

Mitochondrial Fragmentation in Aspergillus fumigatus as Early Marker of Granulocyte Killing Activity

Frontiers in Cellular and Infection Microbiology, 2018
The host's defense against invasive mold infections relies on diverse antimicrobial activities of innate immune cells. However, studying these mechanisms in vitro is complicated by the filamentous nature of such pathogens that typically form long ...
Dominik Ruf, Victor Brantl, Johannes Wagener, Johannes Wagener   +3 more
doaj   +1 more source

Sepsis induces non-classic innate immune memory in granulocytes [PDF]

, 2023
Beibei Wang, Liuluan Zhu, Bei Jia, Chenchen Zhao, Ju Zhang, Fangyuan Li, Jiarui Li, Ding Nan, Can Zhang, Hao Yu, Shuai Tong, Jiajia Wang, Guoli Li, Fan Yang, Henghui Zhang, Rui Li, Juan Du, Yaxian Kong, Yue Zhang, Xiaoyu Yang, Junyan Han, Zhengya Yu, Zhongtao Du, Hong Zheng, Christian Kosan, Ang Li, Chen Chen, Yaluan Ma, Hui Zeng   +28 more
openalex   +1 more source

Whole-blood model reveals granulocytes as key sites of dengue virus propagation, expanding understanding of disease pathogenesis

mBio
Dengue virus (DENV) infection poses a significant global health threat, yet our understanding of its immunopathogenesis remains incomplete due to limitations of existing models.
Hansa Praneechit, Somchai Thiemmeca, Dararat Prayongkul, Kessiri Kongmanas, Dumrong Mairiang, Nuntaya Punyadee, Adisak Songjaeng, Nattaya Tangthawornchaikul, Nasikarn Angkasekwinai, Kanokwan Sriruksa, Yupin Suputtamongkol, Wannee Limpitikul, John P. Atkinson, Panisadee Avirutnan   +13 more
doaj   +1 more source

Detection of Functional Overreaching in Endurance Athletes Using Proteomics

Proteomes, 2018
No reliable biomarkers exist to identify athletes in various training states including functional overreaching (FOR), non-functional overreaching (NFOR), and overtraining syndrome (OTS).
David C. Nieman, Arnoud J. Groen, Artyom Pugachev, Gianmarco Vacca   +3 more
doaj   +1 more source

Efbemalenograstim alfa, an Fc fusion protein, long-acting granulocyte-colony stimulating factor for reducing the risk of febrile neutropenia following chemotherapy: results of a phase III trial [PDF]

, 2023
John A. Glaspy, Igor Bondarenko, Olga Burdaeva, Jianmin Chen, Dean Rutty, Renshu Li, Shufang Wang, Qingsong Hou, Simon Li   +8 more
openalex   +1 more source

Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response. [PDF]

, 2019
A subset of genes in the human genome are uniquely human and not found in other species. One example is CHRFAM7A, a dominant-negative inhibitor of the antiinflammatory α7 nicotinic acetylcholine receptor (α7nAChR/CHRNA7) that is also a neurotransmitter ...
Baird, Andrew, Chan, Theresa W, Cohen, Olga, Costantini, Todd W, Eliceiri, Brian P, Langness, Simone, Treadwell, Sabrina, Williams, Elliot   +7 more
core  

Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis. [PDF]

, 2010
DNAX adaptor protein 12 (DAP12) is a trans-membrane adaptor molecule that transduces activating signals in NK and myeloid cells. Absence of functional Dap12 results in osteoclast defects and bone abnormalities.
Adamopoulos, Iannis E, Antonenko, Svetlana, Bigler, Michael E, Blumenschein, Wendy M, Bowman, Edward P, Chao, Cheng-Chi, Cua, Daniel J, Heyworth, Paul G, Joyce-Shaikh, Barbara, McClanahan, Terrill K, Murphy, Erin E, Phillips, Joseph H   +11 more
core   +3 more sources

Low CD4⁺/CD25⁺/CD127⁻ regulatory T cell- and high INF-γ levels are associated with improved survival of neuroblastoma patients treated with long-term infusion of ch14.18/CHO combined with interleukin-2

OncoImmunology, 2019
Immunotherapy with the anti-GD2 antibody (Ab) ch14.18/CHO in combination with interleukin 2 (IL-2) has improved survival of high-risk neuroblastoma (NB) patients.
Sascha Troschke-Meurer, Nikolai Siebert, Madlen Marx, Maxi Zumpe, Karoline Ehlert, Oliver Mutschlechner, Hans Loibner, Ruth Ladenstein, Holger N. Lode   +8 more
doaj   +1 more source

Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice [PDF]

, 2016
Cell death by apoptosis has a critical role during embryonic development and in maintaining tissue homeostasis. In mammals, there are two converging apoptosis pathways: the ‘extrinsic’ pathway, which is triggered by engagement of cell surface ‘death ...
A Egle, A Enders, A Strasser, A Strasser, A Strasser, A Strasser, A Strasser, A Strasser, A Villunger, AE Weant, AR Delbridge, BA Croker, Cassandra J Vandenberg, DA Hildeman, DA Steimer, E Lagasse, E Schneider, EA Reap, EM Carrington, F Rieux-Laucat, GH Fisher, I Dzhagalov St, I Vikstrom, IN Lavrik, J Hutcheson, J Opferman, JI Fletcher, JJ Weening, JM Brouwer, JT Opferman, K Fecho, K Iwai, K Nakayama, KA Fortner, KD Mason, Kirsteen J Campbell, KJ Campbell, KL O'Neill, L Chen, Lorraine A O’Reilly, M Pellegrini, MN Martina, Natasha S Anstee, P Bouillet, P Hughes, PD Hughes, PE Czabotar, PE Czabotar, Peter D Hughes, PH Krammer, PL Cohen, R Watanabe-Fukunaga, RM Perciavalle, S Cory, S Ogilvy, SF Fischer, SN Willis, SN Willis, Suzanne Cory, T Kuwana, T Moldoveanu, TH Price, TJ McDonnell, V Peperzak, WC Liles, WF Davidson   +65 more
core   +3 more sources