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Chronic granulomatous disease [PDF]

Indian Dermatology Online Journal, 2015
Chronic Granulomatous Disease (CGD) is an inherited immunodeficiency disorder characterized by defective functioning of NADPH oxidase enzyme in the phagocytes.
Kikkeri Narayanasetty Naveen, Adagadde Venkataramana Pradeep   +1 more
doaj   +8 more sources

Chronic granulomatous disease [PDF]

British Medical Bulletin, 2016
Chronic granulomatous disease is a clinical condition that stems from inactivating mutations in NOX2 and its auxiliary proteins. Together, these proteins form the phagocyte NADPH oxidase enzyme that generates superoxide.
Amit Rawat, Sagar Bhattad, Surjit Singh
semanticscholar   +9 more sources

Inherited p40phox deficiency differs from classic chronic granulomatous disease [PDF]

Journal of Clinical Investigation, 2018
Biallelic loss-of-function (LOF) mutations of the NCF4 gene, encoding the p40phox subunit of the phagocyte NADPH oxidase, have been described in only 1 patient. We report on 24 p40phox-deficient patients from 12 additional families in 8 countries.
Dinauer, Mary C, et al,
core   +3 more sources

A case of chronic granulomatous disease and acne: is isotretinoin a safe treatment? [PDF]

Dermatology Reports, 2022
We report the case of a patient with chronic granulomatous disease and acne treated with isotretinoin, who developed a diffuse staphylococcal skin infection during the therapy. Chronic granulomatous disease is a rare genetic disorder characterized by an
Marco Brusasco, Claudio Feliciani, Maria Beatrice de Felici del Giudice   +2 more
doaj   +2 more sources

Chronic Granulomatous Disease

Hematology/Oncology Clinics of North America, 2009
Chronic granulomatous disease (CGD) was first described in the 1950s and has become a paradigm for genetic neutrophil diseases. It is characterized by recurrent infections with a narrow spectrum of bacteria and fungi as well as a common set of inflammatory complications most notably including inflammatory bowel disease. Over the last half century major
Paolo Puccetti, Brahm H. Segal, Luigina Romani   +2 more
semanticscholar   +8 more sources

Aspergillosis in Chronic Granulomatous Disease

Journal of Fungi, 2016
Patients with chronic granulomatous disease (CGD) have the highest life-time incidence of invasive aspergillosis and despite the availability of antifungal prophylaxis, infections by Aspergillus species remain the single most common infectious cause of ...
Jill King, Stefanie S. V. Henriet, Adilia Warris   +2 more
doaj   +2 more sources

Second Report of Chronic Granulomatous Disease in Jordan: Clinical and Genetic Description of 31 Patients From 21 Different Families, Including Families From Lybia and Iraq

Frontiers in Immunology, 2021
Chronic granulomatous Disease (CGD) is a rare innate immunodeficiency disorder caused by mutations in one of the six genes (CYBA, CYBB, NCF1, NCF2, NCF4, and CYBC1/EROS) encoding the superoxide-producing nicotinamide adenine dinucleotide phosphate (NADPH)
Faris Ghalib Bakri, Faris Ghalib Bakri, Michelle Mollin, Sylvain Beaumel, Bénédicte Vigne, Nathalie Roux-Buisson, Nathalie Roux-Buisson, Adel Mohammed Al-Wahadneh, Raed Mohammed Alzyoud, Wail Ahmad Hayajneh, Ammar Khaled Daoud, Mohammed Elian Abu Shukair, Mansour Fuad Karadshe, Mahmoud Mohammad Sarhan, Jamal Ahmad Wadi Al-Ramahi, Julien Fauré, Julien Fauré, John Rendu, John Rendu, Marie Jose Stasia, Marie Jose Stasia   +20 more
doaj   +1 more source

Etiology of granulomatous inflammation: A retrospective study of 174 children in a tertiary care center

Asian Pacific Journal of Tropical Medicine, 2022
Objective: To investigate granulomatous inflammation etiology based on clinical history and ancillary tests. Methods: Children aged
Ummühan Cay, Derya Alabaz, Özlem Özgür Gündeşlioğlu, Aysun Hatice Uguz, Hande Yanar   +4 more
doaj   +1 more source

What Works When Treating Granulomatous Disease in Genetically Undefined CVID? A Systematic Review

Frontiers in Immunology, 2020
BackgroundGranulomatous disease is reported in at least 8–20% of patients with common variable immunodeficiency (CVID). Granulomatous disease mainly affects the lungs, and is associated with significantly higher morbidity and mortality.
Astrid C. van Stigt, Astrid C. van Stigt, Astrid C. van Stigt, Willem A. Dik, Willem A. Dik, Lieke S. J. Kamphuis, Lieke S. J. Kamphuis, Bas M. Smits, Joris M. van Montfrans, P. Martin van Hagen, P. Martin van Hagen, P. Martin van Hagen, Virgil A. S. H. Dalm, Virgil A. S. H. Dalm, Virgil A. S. H. Dalm, Hanna IJspeert, Hanna IJspeert   +16 more
doaj   +1 more source

Chronic granulomatous disease: the European experience. [PDF]

, 2009
CGD is an immunodeficiency caused by deletions or mutations in genes that encode subunits of the leukocyte NADPH oxidase complex. Normally, assembly of the NADPH oxidase complex in phagosomes of certain phagocytic cells leads to a "respiratory burst ...
Ahlin, Anders, Belohradsky, Bernd H., Bernatowska, Ewa, Corbeel, Lucien, Español, Teresa, Fischer, Alain, Kuijpers, Taco W., Kurenko-Deptuch, Magdalena, Mouy, Richard, Petropoulou, Theoni, Roesler, Joachim, Roos, Dirk, Seger, Reinhard, Stasia, Marie-José, Valerius, Niels H., van den Berg, J. Merlijn, van Koppen, Elsbeth, Weening, Ron S., Wolach, Baruch   +18 more
core   +8 more sources