Results 61 to 70 of about 124,897 (378)

Nanoscale Biodegradable Printing for Designed Tuneability of Vaccine Delivery Kinetics

Advanced Materials, EarlyView.
Spatiotemporal Controlled Release Inks of Biocompatible polyEsters (SCRIBE) is a novel 2PP resin family with sub‐micron resolution and tuneable hydrolysis. SCRIBE enables direct printing of hollow microparticles with complex chemistries and geometries inaccessible to molding techniques, which are used to modulate antibody titers and class switching as ...
David J. Peeler, Rujie Sun, Ceren Kütahya, Patrick Peschke, Kun Zhou, Giulia Brachi, Jonathan Yeow, Omar Rifaie‐Graham, Jonathan P. Wojciechowski, Thomas F. F. Fernandez Debets, Vernon LaLone, Xin Song, Krunal Polra, Paul F. McKay, John S. Tregoning, Robin J. Shattock, Molly M. Stevens   +16 more
wiley   +1 more source

Cryptococcus, Pathological observations of five autopsy cases and one biopsy case [PDF]

, 1959
Pathologic, anatomical, and histological findings of 5 autopsy cases and one biopsy case of cryptococcosis have been described. Macroscopically the foci of the lung are grayish white or yellowish white in color and range in size from the small acinous ...
Inohara, Tsuyoshi, Kanamoto, Akihisa, Kuroda, Kiyoshi, Murase, Joji, Ogawa, Katsuo, Uejima, Akira   +5 more
core   +1 more source

Mixture of Input-Output Hidden Markov Models for Heterogeneous Disease Progression Modeling [PDF]

arXiv, 2022
A particular challenge for disease progression modeling is the heterogeneity of a disease and its manifestations in the patients. Existing approaches often assume the presence of a single disease progression characteristics which is unlikely for neurodegenerative disorders such as Parkinson's disease.
arxiv  

Achieving Optimal Health With Host‐Directed Therapies (HDTs) in Infectious Diseases—A New Horizon

Advanced Therapeutics, EarlyView.
Host‐directed therapies (HDTs) represent a transformative approach in infectious disease management by targeting host factors to enhance immune responses and inhibit viral replication. This innovative strategy leverages advanced genomics and gene editing technologies, offering promising avenues for improved patient outcomes and a new horizon in ...
Amol D. Gholap, Pankaj R. Khuspe, Sagar R. Pardeshi, Md Jasim Uddin, Ushasi Das, Navnath T. Hatvate, Satish Rojekar, Prabhanjan Giram, Mohammad Khalid, Yahya E. Choonara, Md. Faiyazuddin   +10 more
wiley   +1 more source

Nanoparticles Combining Host‐Directed Therapeutics and Antibiotics to Boost Bacterial Killing and Overall Survival of Zebrafish Embryos Infected with Mycobacterium Marinum

Advanced Therapeutics, EarlyView.
This study investigates the combination of host‐directed therapeutics (HDT) with antibiotics in a single polymeric micelle based on polypept(o)ides for the therapy of Mycobacterium tuberculosis (Mtb) and ‐marinum (Mm) infections. When the HDT and antibiotic are co‐encapsulated, it significantly reduces bacterial burden in cells and improves overall ...
Gabriela Schäfer, Dongdong Bi, Federico Fenaroli, Andrew M. Thompson, Anno Saris, Matthias Barz   +5 more
wiley   +1 more source

Sarcoidosis Presenting as Acute Respiratory Distress Syndrome. [PDF]

, 2018
Sarcoidosis is a multisystem granulomatous disease of unknown origin. It typically involves the lungs and mediastinal lymph nodes in a chronic fashion. However, acute syndrome has been reported possibly in response to systemic release of proinflammatory ...
Chan, Vincent, Lashari, Bilal, Raza, Ahmad, Ward, William   +3 more
core   +2 more sources

Clinically Relevant Metallic Nanoparticles in Tuberculosis Diagnosis and Therapy

Advanced Therapeutics, EarlyView.
Tuberculosis (TB) remains a global health challenge, with drug‐resistant strains exacerbating the issue. Metallic nanoparticles (MNPs) show promise in TB diagnosis as sensor probes and in combination therapy with antimycobacterial drugs, requiring further pre‐clinical and clinical research for clinical translation.
Christianah Aarinola Akinnawo, Admire Dube   +1 more
wiley   +1 more source

PTPN22 gene polymorphism in Takayasu's arteritis [PDF]

, 2008
Objective. Takayasu's arteritis (TA) is a chronic, rare granulomatous panarteritis of unknown aetiology involving mainly the aorta and its major branches.
Akar, S., Aksu, K., Ateş, A., Bicakcigil, M., Direskeneli, H., Fresko, I., Inanc, M., Kamali, S., Keser, G., Kiraz, S., Onat, A.M., Sahin, N., Saruhan-Direskeneli, G., Tunç, E., Yücel, E., Çobankara, Veli, Özbalkan, Z., Özer, H., Öztürk, M.A.   +18 more
core   +2 more sources

Immunopathogenesis of canine chronic ulcerative stomatitis. [PDF]

, 2020
Canine Chronic Ulcerative Stomatitis is a spontaneously occurring inflammatory disease of the oral mucosa. An immune-mediated pathogenesis is suspected though not yet proven.
Anderson, JG, Bizikova, P, Ford, K, Jimenez, RJ, Kol, A, Murphy, BG, Stapelton, BP, Vasilatis, D, Villarreal, A   +8 more
core   +1 more source

Phase diagram of epidemic spreading - unimodal vs. bimodal probability distributions [PDF]

, 2009
The disease spreading on complex networks is studied in SIR model. Simulations on empirical complex networks reveal two specific regimes of disease spreading: local containment and epidemic outbreak. The variables measuring the extent of disease spreading are in general characterized by a bimodal probability distribution.
arxiv   +1 more source