Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function [PDF]
, 2019 Anovulation is a major cause of infertility, and it is the major leading reproductive disorder in mammalian females. Without ovulation, an oocyte is not released from the ovarian follicle to be fertilized and a corpus luteum is not formed.
Abedel-Majed, Mohamed A. +3 more
core +1 more source
Characteristics and outcome of recurrence in molecularly defined adult-type ovarian granulosa cell tumors [PDF]
, 2016 Objective. Adult-type ovarian granulosa cell tumors (AGCTs) have an unpredictable tendency to relapse. In a carefully validated patient cohort, we evaluated the prognostic factors related to AGCT recurrence. Methods.
Bryk, Saara Susanna +7 more
core +1 more source
Deciphering the skeletal interoceptive circuitry to control bone homeostasis
BMEMat, EarlyView.This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu +7 more
wiley +1 more source
Urology Case Reports, 2017 We report on a case of juvenile granulosa cell tumor of the testicle in a neonate, a rare testicular tumor in children. No genital ambiguity, anatomic abnormalities, nor sex chromosome aneuploidy was noted in this patient.
Melissa Dundas +2 more
doaj +1 more source
miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation. [PDF]
, 2017 Oxidative stress impairs follicular development by inducing granulosa cell (GC) apoptosis, which involves enhancement of the transcriptional activity of the pro-apoptotic factor Forkhead box O1 (FoxO1).
Ding, Lijun +10 more
core +2 more sources
Bee‐Derived Antioxidants as a Protective Strategy Against Doxorubicin‐Induced Ovarian Damage
Chemistry &Biodiversity, EarlyView.Graphical abstract of Bee‐Derived Antioxidants as a Protective Strategy Against Doxorubicin‐Induced Ovarian Damage ABSTRACT Antineoplastic agents can induce tissue damage through oxidative stress mechanisms. Doxorubicin, a widely used chemotherapeutic agent, has been shown to cause permanent damage to reproductive tissues.
Meltem Arıkan Malkoc +3 more
wiley +1 more source
HER2 and GATA4 are new prognostic factors for early-stage ovarian granulosa cell tumor-a long-term follow-up study [PDF]
, 2014 Peer ...
Andersson, Noora Karoliina +6 more
core +1 more source
Ontogeny of RSPO1, FOXL2, and RUNX1 during ovarian differentiation in the marsupial tammar wallaby
Developmental Dynamics, EarlyView.Abstract Background RSPO1 and FOXL2 are female sex‐determining genes involved in the differentiation and organization of the ovary in some eutherian mammals. Mutations or loss of function of these genes are associated with partial to full sex reversal in mice, humans, and goats.
Monika R. Paranjpe +3 more
wiley +1 more source
Co‐existing monophasic teratoma and uterine adenocarcinoma in a female dog [PDF]
, 2019 Ovarian teratomas are occasionally reported in dogs; the rarest type is the monophasic teratoma,composed of tissues originating from only one germ layer. Canine endometrial adenocarcinomas are also rare in dogs and mainly affect geriatric females.
Catarino, J.C +8 more
core +2 more sources
Exploration, EarlyView.Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu +5 more
wiley +1 more source