Results 101 to 110 of about 10,360,699 (193)

The assembly and activation of the PANoptosome promote porcine granulosa cell programmed cell death during follicular atresia

Journal of Animal Science and Biotechnology
Background Follicular atresia significantly impairs female fertility and hastens reproductive senescence. Apoptosis of granulosa cells is the primary cause of follicular atresia.
Hao Wu, Yingxue Han, Jikang Liu, Rong Zhao, Shizhen Dai, Yajun Guo, Nan Li, Feng Yang, Shenming Zeng   +8 more
doaj   +1 more source

TGF-β1 downregulates StAR expression and decreases progesterone production through Smad3 and ERK1/2 signaling pathways in human granulosa cells.

Journal of Clinical Endocrinology and Metabolism, 2014
CONTEXT Regulation of progesterone production in granulosa cells is important for normal reproductive functions. Steroidogenic acute regulatory protein (StAR) is recognized as the key regulatory protein involved in the rate-limiting step of ...
Lanlan Fang, Hsun‐Ming Chang, Jung-Chien Cheng, P. Leung, Ying-pu Sun   +4 more
semanticscholar   +1 more source

Multi‐Omics Reveal the Metabolic Changes in Cumulus Cells During Aging

Cell Proliferation, EarlyView.
Fatty acid β‐oxidation was elevated in cumulus cells from older mice. Tryptophan metabolism in aged cumulus cells was active. Supplementing with 5‐HT could mitigate aging damage in oocytes. ABSTRACT Maternal age has been reported to impair oocyte quality.
Liangyue Shi, Hengjie Wang, Shuai Zhu, Minjian Chen, Xuejiang Guo, Qiang Wang, Ling Gu   +6 more
wiley   +1 more source

The effect of total flavonoids of Epimedium on granulosa cell development in laying hens

Poultry Science, 2020
To investigate the impact of total flavonoids of Epimedium (TFE) on the development of follicles of laying hens, 3 types of follicles including primary, prehierarchical, and preovulatory follicles were selected to obtain the follicular granulosa cells ...
Yu Guo, Yurong Li, Shuang Zhang, Xianjun Wu, Luying Jiang, Qianhui Zhao, Wenhui Xue, Shuying Huo   +7 more
doaj  

Melatonin Does Not Affect Progesterone Basal Secretion but Suppresses the Luteinizing Hormone Receptor Expression in Granulosa Cells of the Japanese Quail

The Journal of Poultry Science, 2017
The aim of this study was to evaluate the potential effect of melatonin on progesterone production by granulosa cells of the Japanese quail. For in vitro experiments, granulosa cells were isolated from pre-ovulatory follicles (F1-F3) when the F1 ...
Guang-Min Yu, Naoki Isobe, Teruo Maeda
doaj   +1 more source

Multiple Metastases to the Lungs 14 Years After Surgery for Adult‐Type Granular Cell Tumor of the Ovary

The Kaohsiung Journal of Medical Sciences, EarlyView.
Di‐Ping Yu, Liu‐Qing Yang
wiley   +1 more source

Decoding the Molecular Landscape of Prepubertal Oocyte Maturation: GTPBP4 as a Key Driver of In Vitro Developmental Competence

Cell Proliferation, EarlyView.
Transcriptional and translational characteristics during goat oocyte maturation and identification of key factors, including GTPBP4, for prepubertal goat oocyte maturation. ABSTRACT The intricate mechanisms driving oocyte maturation remain only partially understood, especially within the domains of domestic animal reproduction and translational ...
Jianpeng Qin, Yaozong Wei, Ao Ning, Wenqi Hu, Pengcheng Wan, Beijia Cao, Bo Pan, Tianyi Lv, Kunlin Du, Xueling Yao, Shuqi Zou, Xiangyi Chen, Shengqin Zang, Jiangfeng Ye, Guozhi Yu, Qiuxia Liang, Liuhong Shen, Lin Zhang, Xiang Chen, Keren Cheng, Li Meng, Guangbin Zhou   +21 more
wiley   +1 more source

Follicular growth and atresia in mammalian ovaries: regulation by survival and death of granulosa cells.

Journal of reproduction and development, 2012
The mammalian ovary is an extremely dynamic organ in which a large majority of follicles are effectively eliminated throughout their reproductive life.
Fuko Matsuda, Naoko Inoue, N. Manabe, S. Ohkura   +3 more
semanticscholar   +1 more source

GPD1L‐Mediated Glycerophospholipid Metabolism Dysfunction in Women With Diminished Ovarian Reserve: Insights From Pseudotargeted Metabolomic Analysis of Follicular Fluid

Cell Proliferation, EarlyView.
Our study demonstrated the downregulation of GPD1L and its mediated glycerophospholipid metabolism dysfunction in patients with diminished ovarian reserve. Moreover, we verified that GPD1L knockdown leads to increased cell apoptosis and mitochondrial dysfunction of KGN cells, as well as impaired oocyte quality.
Jiaqi Wu, Xuehan Zhao, Ying Fang, Cong Wang, Yichang Tian, Wan Tu, Qiqian Wu, Long Yan, Xiaokui Yang   +8 more
wiley   +1 more source

Pathogen-associated molecular patterns initiate inflammation and perturb the endocrine function of bovine granulosa cells from ovarian dominant follicles via TLR2 and TLR4 pathways.

Endocrinology, 2013
Bacterial infections of the uterus or mammary gland commonly cause disease and infertility by perturbing growth and steroidogenesis of the dominant follicle in the ovary of cattle. Cells of the innate immune system use Toll-like receptors TLR2, TLR4, and
Jennifer C. Price, John J. Bromfield, I. M. Sheldon   +2 more
semanticscholar   +1 more source