Results 51 to 60 of about 10,360,699 (193)
Cells, 2022 Here, we applied a model of long-term exposure of human granulosa cells to low environmentally relevant levels of di(2-ethylhexyl) phthalate (DEHP). This approach provides more relevant data regarding the impact of DEHP on the function of human granulosa
Dragana Samardzija Nenadov +6 more
doaj +1 more source
Does BPA alter steroid hormone synthesis in human granulosa cells in vitro?
Human Reproduction, 2016 STUDY QUESTION Does Bisphenol A (BPA) impair steroid hormone production in human luteinized granulosa cells in vitro? SUMMARY ANSWER At supra-physiological concentrations, BPA alters progesterone and estradiol synthesis in vitro and significantly ...
Abdallah Mansur +7 more
semanticscholar +1 more source
Advanced Science, EarlyView.LRRC4 deficiency disrupts the metabolic homeostasis of mitochondrial aerobic respiration and glycolysis during GC differentiation by inhibiting the ubiquitination‐mediated degradation of YAP, which ultimately leads to POI. These findings reveal the novel molecular etiology of POI and provide a promising target for prevention and treatment.
Yujie Shang +5 more
wiley +1 more source
Lipopolysaccharide alters CEBPβ signaling and reduces estradiol production in bovine granulosa cells
CABI Agriculture and Bioscience, 2022 Background Bacterial infection of the uterus in postpartum dairy cows limits ovarian follicle growth, reduces blood estradiol concentrations, and leads to accumulation of bacterial lipopolysaccharide (LPS) in ovarian follicular fluid.
Mackenzie J. Dickson +2 more
doaj +1 more source
Cell Death and Disease, 2022 Endometriosis (EMs) occurs in approximately 50% of women with infertility. The main causes of EMs-related infertility are follicle dysplasia and reduced oocyte quality.
Zhexin Ni +12 more
semanticscholar +1 more source
Advanced Science, EarlyView.RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang +7 more
wiley +1 more source
HOX cofactors expression and regulation in the human ovary
Reproductive Biology and Endocrinology, 2008 Background HOX cofactors enhance HOX binding affinities and specificities and increase HOX's unique functional activities. The expression and the regulation of HOX cofactors in human ovaries are unknown.
Auersperg Nelly +6 more
doaj +1 more source
Journal of Clinical Endocrinology and Metabolism, 2016 CONTEXT Insulin resistance (IR) of the granulosa cells may account for the ovarian dysfunctions observed in polycystic ovarian syndrome (PCOS). The underlying mechanism remains largely unresolved. OBJECTIVE The objective of the study was to investigate
Qinling Zhu +6 more
semanticscholar +1 more source
Animal Research and One Health, EarlyView.The paper is divided into three main sections: a review of the development of spatial transcriptomics technology, its applications in livestock and poultry research, and its future prospects. This article provides an overview of the current state of spatial transcriptomics in animal research, exploring its integration with multiomics technologies as ...
Mingyu Wang +5 more
wiley +1 more source
Nature Communications, 2015 Organogenesis of the ovary is a highly orchestrated process involving multiple lineage determination of ovarian surface epithelium, granulosa cells and theca cells.
Chang Liu, Jia Peng, M. Matzuk, H. Yao
semanticscholar +1 more source