Results 261 to 270 of about 78,948 (301)
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Immunological Reviews, 2010
Summary: Cytotoxic lymphocytes are armed with granules that are released in the granule‐exocytosis pathway to kill tumor cells and virus‐infected cells. Cytotoxic granules contain the pore‐forming protein perforin and a family of structurally homologues serine proteases called granzymes.
Niels, Bovenschen, J Alain, Kummer
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Summary: Cytotoxic lymphocytes are armed with granules that are released in the granule‐exocytosis pathway to kill tumor cells and virus‐infected cells. Cytotoxic granules contain the pore‐forming protein perforin and a family of structurally homologues serine proteases called granzymes.
Niels, Bovenschen, J Alain, Kummer
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Granzyme A is a proinflammatory protease
Blood, 2009To the editor: We have read with great interest the paper by Zhu et al[1][1] that suggests poly ADP ribose polymerase 1 (PARP-1) is cleaved when granzyme A (gzmA) enters target cells. This new finding may have implications for the proinflammatory effects of this protease.[2][2][⇓][3]–[4][4]
Julián, Pardo +2 more
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Human neutrophils lack granzyme A, granzyme B, and perforin
Blood, 2004Wagner et al[1][1] and Hochegger et al[2][2] reported that human polymorphonuclear neutrophils (PMNs) express granzyme A (GzmA), granzyme B (GzmB), and perforin (PFN), postulating a role for these granule proteins in PMN-mediated antibody-dependent cellular cytotoxicity.
Sunil S. Metkar, Christopher J. Froelich
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Granzyme B: a natural born killer
Immunological Reviews, 2003Summary: A main pathway used by cytotoxic T lymphocytes (CTLs) and natural killer cells to eliminate pathogenic cells is via exocytosis of granule components in the direction of the target cell, delivering a lethal hit of cytolytic molecules. Amongst these, granzyme B and perforin have been shown to induce CTL‐mediated target cell DNA fragmentation ...
Sarah J, Lord +3 more
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Nuclear war: the granzyme A-bomb
Current Opinion in Immunology, 2003Granzyme A, a serine protease in the cytotoxic granules of natural killer cells and cytotoxic T lymphocytes, induces caspase-independent cell death when introduced into target cells by perforin. Granzyme A induces single-stranded DNA damage as well as rapid loss of cell membrane integrity and mitochondrial transmembrane potential through unknown ...
Judy, Lieberman, Zusen, Fan
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Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis [PDF]
Cell Death and Differentiation, 2013 Human and mouse granzyme (Gzm)B both induce target cell apoptosis in concert with pore-forming perforin (Pfp); however the mechanisms by which other Gzms induce non-apoptotic death remain controversial and poorly characterised. We used timelapse microscopy to document, quantitatively and in real time, the death of target cells exposed to primary ...
Sarah E Stewart, Ilia Voskoboinik
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1994
Publisher Summary Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells of human, mouse, and rat origin express a large number of homologous serine proteinases. These proteinases are termed “granzymes,” as they are stored within cytoplasmic granules.
Markus M. Simon, Michael D. Kramer
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Publisher Summary Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells of human, mouse, and rat origin express a large number of homologous serine proteinases. These proteinases are termed “granzymes,” as they are stored within cytoplasmic granules.
Markus M. Simon, Michael D. Kramer
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Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus α-thrombin
The Journal of Immunology, 1996Abstract Granzymes, serine proteases located in the granules of cytotoxic T cel ls and NK cells, are essential for induction of target cell apoptosis. However, since cytotoxic cells constitutively secrete a portion of their synthesized granzymes, these proteases could mediate extracellular functions independent of their role in the lytic
L E Sower +5 more
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Journal of Immunological Methods, 2004
Graft-versus-host disease (GvHD) can be a major complication after allogeneic stem cell transplantation (SCT) especially when donor and recipient are unrelated. The latter serious complication, together with the growing number of available unrelated stem cell donors, demand a simple in vitro assay for functional stem cell donor selection.
Kircher B +10 more
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Graft-versus-host disease (GvHD) can be a major complication after allogeneic stem cell transplantation (SCT) especially when donor and recipient are unrelated. The latter serious complication, together with the growing number of available unrelated stem cell donors, demand a simple in vitro assay for functional stem cell donor selection.
Kircher B +10 more
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Granzyme A: the road less traveled
Nature Immunology, 2003Cellular parasites have evolved clever anti-apoptosis strategies to avoid being killed by CTLs. However, CTL release of granzyme A inactivates a key repair enzyme, Ape1, ensuring death of infected cells.
Michael J. Pinkoski, Douglas R. Green
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