Results 271 to 280 of about 78,948 (301)
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The substrate specificity profile of human granzyme A
Biological Chemistry, 2010Abstract The exact biological function of granzyme A, a granule-associated serine protease belonging to the tryptase family of proteases, is still a matter of debate because conflicting roles have been suggested, such as initiation of caspase-independent apoptosis-like cell death and endogenous modulation of inflammatory processes.
Petra, Van Damme +7 more
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Inhibition of lymphocyte protease granzyme A by antithrombin III
Molecular Immunology, 1988T-lymphocytes contain a cytoplasmic granule associated homo-dimeric protease designated granzyme A. Upon T-cell target cell interaction, the granules undergo exocytosis and granzyme A, and other granule constituents, are released. Here we show that granzyme A secreted into plasma is immediately inactivated by antithrombin III.
D, Masson, J, Tschopp
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Granzyme B as a therapeutic target for wound healing
Expert Opinion on Therapeutic Targets, 2019Introduction: Granzyme B is a serine protease traditionally understood as having a role in immune-mediated cytotoxicity. Over the past decade, this dogma has been challenged, with a new appreciation that granzyme B can exert alternative extracellular roles detrimental to wound closure and remodeling. Granzyme B is elevated in response to tissue injury,
Christopher T, Turner +2 more
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International Journal of Molecular Medicine, 2006
Pentoxifylline (PTX) is an unspecific inhibitor of phosphodiesterase activity that increases intracellular concentration of cyclic nucleotides, mainly cAMP. Since PTX improves microcirculatory blood flow, it is commonly and often chronically used in peripheral vascular diseases.
Maciej, Lazarczyk +7 more
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Pentoxifylline (PTX) is an unspecific inhibitor of phosphodiesterase activity that increases intracellular concentration of cyclic nucleotides, mainly cAMP. Since PTX improves microcirculatory blood flow, it is commonly and often chronically used in peripheral vascular diseases.
Maciej, Lazarczyk +7 more
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Journal of immunology (Baltimore, Md. : 1950), 1996
Granzymes, serine proteases located in the granules of cytotoxic T cel ls and NK cells, are essential for induction of target cell apoptosis. However, since cytotoxic cells constitutively secrete a portion of their synthesized granzymes, these proteases could mediate extracellular functions independent of their role in the lytic event.
L E, Sower +5 more
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Granzymes, serine proteases located in the granules of cytotoxic T cel ls and NK cells, are essential for induction of target cell apoptosis. However, since cytotoxic cells constitutively secrete a portion of their synthesized granzymes, these proteases could mediate extracellular functions independent of their role in the lytic event.
L E, Sower +5 more
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Substrate Specificities of the Granzyme Tryptases A and K
Journal of Proteome Research, 2014The physiological roles of the granzymes A and K have been debated, especially concerning their involvement in cytotoxic and inflammatory processes. By performing N-terminal COFRADIC assisted N-terminomics on the homologous human granzymes A and K, we here provide detailed data on their substrate repertoires, their specificities, and differences in ...
Kim, Plasman +4 more
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Granzyme B is a novel interleukin-18 converting enzyme
Journal of Dermatological Science, 2010Granzyme B (GrB) is recognized to induce apoptosis; however, little is known about its possible role in other biological events. IL-18, a potent inflammatory cytokine, is produced as an inactive precursor (proIL-18). Several cells, including monocytes/macrophage lineage and non-hematopoietic cells such as keratinocytes, produce proIL-18.
Youichi, Omoto +12 more
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Granzyme N, a novel granzyme, is expressed in spermatocytes and spermatids of the mouse testis.
Biology of reproduction, 2005We cloned a cDNA for a novel granzyme, granzyme N (Gzmn), from a mouse testes cDNA library. The testes contained two distinct species of Gzmn mRNA, one of which codes for a complete protein of 248 amino acids with three essential residues required for catalytic activity. The Gzmn mRNA was specifically expressed in the testes of adult mice.
Naoharu, Takano +2 more
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Cytotoxic granzyme C–expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity
Science Immunology, 2022Briana Nixon, Chun Chou, Chirag Krishna
exaly