Results 21 to 30 of about 78,948 (301)

Contact-Dependent Granzyme B-Mediated Cytotoxicity of Th17-Polarized Cells Toward Human Oligodendrocytes

Frontiers in Immunology, 2022
Multiple sclerosis (MS) is characterized by the loss of myelin and of myelin-producing oligodendrocytes (OLs) in the central nervous system (CNS). Pro-inflammatory CD4+ Th17 cells are considered pathogenic in MS and are harmful to OLs.
Hélène Jamann, Hélène Jamann, Qiao-Ling Cui, Haritha L. Desu, Haritha L. Desu, Florian Pernin, Olivier Tastet, Alexandre Halaweh, Alexandre Halaweh, Negar Farzam-kia, Negar Farzam-kia, Victoria Hannah Mamane, Victoria Hannah Mamane, Oumarou Ouédraogo, Oumarou Ouédraogo, Aurélie Cleret-Buhot, Audrey Daigneault, Renaud Balthazard, Renaud Balthazard, Wendy Klement, Wendy Klement, Florent Lemaître, Florent Lemaître, Nathalie Arbour, Nathalie Arbour, Jack Antel, Jo Anne Stratton, Catherine Larochelle, Catherine Larochelle   +28 more
doaj   +1 more source

Granzyme A, a Stealth Killer in the Mitochondrion [PDF]

Cell, 2008
The induction of caspase-independent cell death by killer lymphocytes involves the serine protease granzyme A (GzmA). In this issue, Martinvalet et al. (2008) show that GzmA penetrates the mitochondrial matrix without perturbing normal mitochondrial functions. In the mitochondrial matrix, GzmA cleaves NDUFS3 (a component of the electron transport chain)
Lucken-Ardjomande, Safa, Martinou, Jean-Claude   +1 more
openaire   +3 more sources

Study of serum Granzyme B in heavy cigarette smokers with and without chronic obstructive pulmonary disease

Egyptian Journal of Chest Disease and Tuberculosis, 2014
Background: Inflammation of the airways is present in COPD with increased number of inflammatory cells including killer cells that lyse their target cells by two mechanisms; membranolysis in which secreted molecules such as granzymes form pores in the ...
Ahmed A. Yousef, Mahmoud M. Alsalahy, Mohammad A. Almahdy, Tarek S. Essawy, Khalid M. Belal   +4 more
doaj   +1 more source

Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells : implications for adoptive immunotherapy after allogeneic stem cell transplantation [PDF]

, 2010
Background: Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood and has a poor prognosis. Here we assessed the capability of ex vivo expanded cytokine-induced killer cells to lyse both alveolar and embryonic rhabdomyosarcoma cell lines ...
Kuçi, Selim, Rettinger, Eva, Voß, Bernhard, Weber, Gerrit, Stais, Miriam, Kreyenberg, Hermann, Willasch, Andre Manfred, Kuçi, Zyrafete, Koscielniak, Ewa, Klöß, Stephan, Laer, Dorothee von, Klingebiel, Thomas, Bader, Peter   +12 more
core   +1 more source

Study of effect of inhaled versus oral corticosteroids on sputum granzyme B in patients with moderate persistent bronchial asthma

Egyptian Journal of Chest Disease and Tuberculosis, 2015
Background: Asthma is a major public health problem with a high economic burden. It involves several inflammatory cells and multiple mediators. Granzyme B is an inflammatory mediator expressed and secreted by both immune and non immune cells. Recently it
Walaa K. Shoeib, Mahmoud M. Alsalahy, Mohammad A. Almahdy, Tarek S. Essawy, Khalid M. Belal   +4 more
doaj   +1 more source

NF-κB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells

Frontiers in Immunology, 2021
Natural Killer (NK) cells are cytotoxic lymphocytes critical to the innate immune system. We found that germline deficiency of NF-κB c-Rel results in a marked decrease in cytotoxic function of NK cells, both in vitro and in vivo, with no significant ...
Yorleny Vicioso, Derek P. Wong, Nand K. Roy, Nayanika Das, Keman Zhang, Parameswaran Ramakrishnan, Parameswaran Ramakrishnan, Reshmi Parameswaran, Reshmi Parameswaran   +8 more
doaj   +1 more source

GZMA (granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on GZMA (granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)), with data on DNA, on the protein encoded, and where the gene is implicated.
Catalan, E, Sanchez-Martinez, D, Pardo, J   +2 more
openaire   +2 more sources

HLA-DR in Cytotoxic T lymphocytes predicts breast cancer patients' response to neoadjuvant chemotherapy [PDF]

, 2018
Prediction of breast cancer response to Neoadjuvant Chemotherapy (NACT) is an urgent need to promptly direct non-responder patients to alternative therapies.
Borralho, Paula, Braga, Sofia, Cabral, M. Guadalupe, Jacinto, António, Saraiva, Diana P.   +4 more
core   +2 more sources

Granzyme B PET Imaging of the Innate Immune Response

Molecules, 2020
The human immune system is a complex system which protects against invaders and maintains tissue homeostasis. It is broadly divided into the innate and adaptive branches. Granzyme B is serine protease that plays an important role in both and can serve as
Kathleen M. Capaccione, Mikhail Doubrovin, Nikunj Bhatt, Akiva Mintz, Andrei Molotkov   +4 more
doaj   +1 more source

Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection. [PDF]

, 2017
The gastrointestinal mucosa is an important site of HIV acquisition, viral replication, and pathogenesis. Immune cells in mucosal tissues frequently differ in phenotype and function from their non-mucosal counterparts.
Critchfield, JW, Deeks, SG, Ganesh, A, Hecht, FM, Hunt, PW, Kiniry, BE, Shacklett, BL, Somsouk, M   +7 more
core   +1 more source