Results 131 to 140 of about 52,710 (257)

Granzyme B from mast cells contributes to choroidal neovascularization in a model of wet age-related macular degeneration. [PDF]

Front Immunol
Uppal M, Hosseini A, Bilal K, Tan N, Ai Z, Khan W, Samad I, Gill G, Yoo HS, Chakravarthy H, Kuo CH, Xi J, Granville DJ, Matsubara JA.   +13 more
europepmc   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Granzyme B-Targeting Quenched Activity-Based Probes for Assessing Tumor Response to Immunotherapy. [PDF]

J Am Chem Soc
Kazim M, Ganguly A, Malespini SM, Thang L, Patel NL, Kim C, Thakur K, Kalen JD, Calcagno C, Difilippantonio S, Yoo E.   +10 more
europepmc   +1 more source

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, EarlyView.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

Anti‐NMDA receptor autoimmune encephalitis associated with ovarian teratoma: A case series and literature review

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 23-30, April 2025.
Abstract Autoimmune encephalitis is a group of disorders characterized by symptoms of dysfunction of the limbic and extra‐limbic systems that occur in association with antibodies against intracellular antigens, synapses, or proteins located on the surface of nerve cells. Anti‐NMDA (N‐methyl‐D‐aspartate) receptor encephalitis was first described in 2007
Pham Ba Nha, Nguyen Phuong Tu, Nguyen Viet Ha, Duong Thi Thu Hien, Nguyen Thi Thu Phuong, Nguyen Anh Son, Nguyen Tien Hoang   +6 more
wiley   +1 more source

Granzyme B-producing B cells: a bidirectional relationship with breast cancer cells and implications for immunotherapy. [PDF]

Am J Clin Exp Immunol
Hakimi H, Mehdipour F, Samadi M, Balouchi Anaraki S, Rasolmali R, Talei AR, Ghaderi A.   +6 more
europepmc   +1 more source

Bile acid metabolism and signaling in human and animal health: A One Health perspective

iMetaOmics, EarlyView.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li, Shuai Liu, Zhijun Cao, Yangchun Cao, Shengru Wu, Lu Deng, Junhu Yao, Jun Zhang   +7 more
wiley   +1 more source

Quantitative dynamic granzyme B PET imaging to characterize novel combination immunotherapy response in preclinical glioblastoma models. [PDF]

Theranostics
Gallegos CA, Lu Y, Song PN, Queiroz R, Akca U, Sridhar S, Bartels JL, Zhang Y, Li L, Warram JM, Lapi SE, Larimer BM, Markert JM, Sorace AG.   +13 more
europepmc   +1 more source

Does the expression of granzyme B participate in inflammation, fibrosis, and fertility of hydatid cysts? [PDF]

Parasitol Res, 2023
Sweed D, Mohamady M, Gouda MA, Fayed Y, Saied SA, Elhamed SMA.   +5 more
europepmc   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source