Results 241 to 250 of about 78,129 (305)

GrB-Fc-KS49, an anti-EMP2 granzyme B fusion protein therapeutic alters immune cell infiltration and suppresses breast cancer growth. [PDF]

J Immunother Cancer
Mohamedali KA, Aguirre B, Lu CH, Chandla A, Kejriwal N, Liu L, Chan AM, Cheung LH, Kok S, Duarte S, Alvarez de Cienfuegos A, Casero D, Rosenblum MG, Wadehra M.   +13 more
europepmc   +1 more source

Study on the Function and Mechanism of Neutrophil Extracellular Traps in Regulating Necroptosis Following Traumatic Brain Injury

Brain and Behavior, Volume 16, Issue 3, March 2026.
TBI induces NETs formation, as evidenced by the upregulation of PAD4 and MPO. NETs activate the necroptosis pathway via phosphorylation of RIP1‐RIP3‐MLKL, thereby exacerbating secondary brain injury (neuronal death, BBB disruption, and neuroinflammation).
Ao Li, Tian‐Wei Pei, Hao Qi, Li‐Biao Song, Juan Fang, Zhi‐Song Ding, Tao Chen   +6 more
wiley   +1 more source

SLC12A8 Drives Immune Evasion and Metastasis in Luminal B Breast Cancer by Inducing CD8+ T‐Cell Exhaustion via the TLR Signaling Pathway

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background To investigate the role and mechanism of SLC12A8 in the progression of Luminal B breast cancer. Methods Data from TCGA, GTEx, and HPA databases were used to analyze SLC12A8 expression and its prognostic value in breast cancer. qPCR was performed to validate SLC12A8 expression in various breast cancer cell lines.
Zhiyong Liu, Ran Chen
wiley   +1 more source

Reassessing granzyme B: unveiling perforin-independent versatility in immune responses and therapeutic potentials. [PDF]

Front Immunol
Thompson R, Cao X.
europepmc   +1 more source

A Link Between Allergy and Hematological Malignancies? Focus on Possible Mechanisms and the Potential Role of Biological Therapies

Clinical and Translational Allergy, Volume 16, Issue 3, March 2026.
ABSTRACT Immune dysregulation has been widely recognized in the international literature as an underlying condition for hematological malignancies and allergic disorders. This commonality has led researchers to study the potential association, positive or negative, between blood cancers and allergy, but the results remain unclear.
Stefania Isola, Luca Gammeri, Federica Nuccio, Alessandro Allegra, Giorgio Walter Canonica, Sebastiano Gangemi   +5 more
wiley   +1 more source

Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization. [PDF]

Angiogenesis
Obasanmi G, Uppal M, Cui JZ, Xi J, Ju MJ, Song J, To E, Li S, Khan W, Cheng D, Zhu J, Irani L, Samad I, Zhu J, Yoo HS, Aubert A, Stoddard J, Neuringer M, Granville DJ, Matsubara JA.   +19 more
europepmc   +1 more source

Mass Cytometry Workflow to Achieve High‐Dimensional Immunophenotyping in Resource‐Limited or Decentralized Environments

Current Protocols, Volume 6, Issue 3, March 2026.
Abstract Globally, regional and remote communities are burdened by both an increased prevalence and worse prognosis of many infectious and chronic diseases. However, largely owing to logistical challenges, these communities are under‐represented in clinical trials and research studies.
Natalie Smith, Michael Cohen, Lauren Tracey, Julie Alipaz, Christina Loh, David King, Neha Pulyani, Rebecca Auzins, Elin Gray, Sandra Taylor, Rajat Rai, Steven Kao, Barbara Fazekas de St Groth, Helen McGuire   +13 more
wiley   +1 more source

New roles for the major human 3\u27–5\u27 exonuclease TREX1 in human disease [PDF]

, 2008
Atkinson, John P, Kavanagh, David, Kothari, Parul H, Liszewski, M Kathryn, Richards, Anna, Shaikh, Aisha, Spitzer, Dirk   +6 more
core   +1 more source

Overexpression of ST8Sia1 inhibits tumor progression by TGF-β1 signaling in rectal adenocarcinoma and promotes the tumoricidal effects of CD8⁺ T cells by granzyme B and perforin. [PDF]

Ann Med
Zhang C, Wang Y, Yu Y, Pang Y, Xiao X, Hao L.   +5 more
europepmc   +1 more source

Cellular Immune Response Induced by mRNA Vaccines Against SARS‐CoV‐2

Immunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.
SARS‐CoV‐2 vaccine induces cellular immune response. T‐cells play a protective role for COVID‐19. ABSTRACT The disease caused by SARS‐CoV‐2 is known as COVID‐19, and it can range from mild symptoms to severe clinical manifestations, including respiratory failure, pneumonia, and organ failure. Since its emergence in 2019, more than 7 million deaths have
Valentina Tovar, Isaura Pilar Sánchez, María Teresa Rugeles, Natalia Andrea Taborda, Juan C. Hernandez   +4 more
wiley   +1 more source