Results 41 to 50 of about 373,959 (290)

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Nutrition Profile and Animal-Tested Safety of Morchella esculenta Mycelia Produced by Fermentation in Bioreactors

Foods, 2022
Morchella esculenta (ME), or “true” morel mushrooms, are one of the most expensive mushrooms. M. esculenta contain all the important nutrients including carbohydrates, proteins, polyunsaturated fatty acids, and several bioactive compounds such as ...
I-Chen Li, Lynn-Huey Chiang, Szu-Yin Wu, Yang-Chia Shih, Chin-Chu Chen   +4 more
doaj   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

PROGRAPE-1: A Programmable, Multi-Purpose Computer for Many-Body Simulations [PDF]

, 1999
We have developed PROGRAPE-1 (PROgrammable GRAPE-1), a programmable multi-purpose computer for many-body simulations. The main difference between PROGRAPE-1 and "traditional" GRAPE systems is that the former uses FPGA (Field Programmable Gate Array ...
Fukushige, Toshiyuki, Hamada, Tsuyoshi, Kawai, Atsushi, Makino, Junichiro   +3 more
core   +4 more sources

Plant Robotics for Sustainable and Environmentally Friendly Robots: Insights from Actuation Characteristics

Advanced Science, EarlyView.
Plants are promising materials for building sustainable and eco‐friendly robots due to their inherent multifunctionality, with actuation playing a crucial role. This article focuses on the physical movements of plants and, from the perspective of actuation characteristics, explores representative plant species and their behaviors, the current state of ...
Kazuya Murakami, Misao Sato, Yu Ikeda, Tatsuhiro Horii, Yukari Nagatoshi, Miki Fujita, Toshinori Fujie, Yasunari Fujita, Jun Shintake   +8 more
wiley   +1 more source

RNA-Seq reveals new DELLA targets and regulation in transgenic GA-insensitive grapevines

BMC Plant Biology, 2019
Background Gibberellins (GAs) and their regulator DELLA are involved in many aspects of plant growth and development and most of our current knowledge in the DELLA-facilitated GA signaling was obtained from the studies of annual species. To understand GA-
Jie Arro, Yingzhen Yang, Guo-Qing Song, Gan-Yuan Zhong   +3 more
doaj   +1 more source

Developing a Compton Polarimeter to Measure Polarization of Hard X-Rays in the 50-300 keV Energy Range [PDF]

, 2005
This paper discusses the latest progress in the development of GRAPE (Gamma-Ray Polarimeter Experiment), a hard X-ray Compton Polarimeter. The purpose of GRAPE is to measure the polarization of hard X-rays in the 50-300 keV energy range.
Bloser, P., Legere, J. S., Macri, J. R., McConnell, M. L., Narita, T., Ryan, J. M.   +5 more
core   +3 more sources

Multimodal Optical Imaging and Modulation with Simultaneous Electrophysiology Through Smart Dura in Non‐Human Primates

Advanced Science, EarlyView.
This study demonstrates multimodal integration in non‐human primates, combining large‐scale, high‐density electrophysiology using Smart Dura with optical techniques such as multiphoton imaging (MPI), photothrombotic lesioning, optical coherence tomography angiography (OCTA), wide‐field intrinsic signal optical imaging (ISOI), and optogenetics.
Nari Hong, Sergio Montalvo Vargo, Gaku Hatanaka, Zhaoyu Gong, Noah Stanis, Jasmine Zhou, Tiphaine Belloir, Ruikang K. Wang, Wyeth Bair, Maysamreza Chamanzar, Azadeh Yazdan‐Shahmorad   +10 more
wiley   +1 more source

Genome-wide identification and characterization of the LRX gene family in grapevine (Vitis vinifera L.) and functional characterization of VvLRX7 in plant salt response

BMC Genomics
Background Leucine-rich repeat (LRR) extensins (LRXs), which are cell wall-localized chimeric extensin proteins, are essential for the development of plants and their resistance to stress. Despite the significance of these genes, an extensive genome-wide
Kai Liu, Xiujie Li, Chaoping Wang, Yan Han, Ziguo Zhu, Bo Li   +5 more
doaj   +1 more source

A pilgrimage to gravity on GPUs [PDF]

, 2012
In this short review we present the developments over the last 5 decades that have led to the use of Graphics Processing Units (GPUs) for astrophysical simulations. Since the introduction of NVIDIA's Compute Unified Device Architecture (CUDA) in 2007 the
A. Ahmad, A. Gualandris, A. Tanikawa, E. Gaburov, E. Holmberg, E.N. Dorband, G.J. Sussman, J. Barnes, J. Bédorf, J. Bédorf, J. Goodman, J. Makino, J.H. Applegate, J.R. Hurley, K. Nitadori, L. Nyland, M. Fujii, P. Hut, R. Spurzem, R. Spurzem, R. Spurzem, R. Yokota, R.G. Belleman, R.H. Miller, S. Harfst, S. Inagaki, S. Portegies Zwart, S. Portegies Zwart, S. Portegies Zwart, S. von Hoerner, S.F. Portegies Zwart, S.F. Portegies Zwart, S.J. Aarseth, S.J. Aarseth, T. Fukushige, T.S. van Albada, W. Dehnen, W. Dehnen   +37 more
core   +3 more sources