Results 91 to 100 of about 3,684,752 (344)

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Anatomy of a Data Science Software Toolkit That Uses Machine Learning to Aid ‘Bench-to-Bedside’ Medical Research—With Essential Concepts of Data Mining and Analysis Explained

Applied Sciences, 2021
Data science and machine learning are buzzwords of the early 21st century. Now pervasive through human civilization, how do these concepts translate to use by researchers and clinicians in the life-science and medical field?
László Beinrohr, Eszter Kail, Péter Piros, Erzsébet Tóth, Rita Fleiner, Krasimir Kolev   +5 more
doaj   +1 more source

Semantic acyclicity on graph databases [PDF]

Proceedings of the 32nd ACM SIGMOD-SIGACT-SIGAI symposium on Principles of database systems, 2013
It is known that unions of acyclic conjunctive queries (CQs) can be evaluated in linear time, as opposed to arbitrary CQs, for which the evaluation problem is NP-complete. It follows from techniques in the area of constraint-satisfaction problems that semantically acyclic unions of CQs---i.e., unions of CQs that are equivalent to a union of acyclic ...
Barceló Baeza, Pablo, Romero Orth, Miguel, Vardi, Moshe   +2 more
openaire   +4 more sources

Graph Locality Prefetcher for Graph Database [PDF]

, 2016
This work presents a hardware prefetcher to improve the performance of accessing graph data representing large and complex networks. We represent complex networks as graphs, and queries amount to traversals on the graph.
Yin, Zhuoran
core  

The Gremlin Graph Traversal Machine and Language

, 2015
Gremlin is a graph traversal machine and language designed, developed, and distributed by the Apache TinkerPop project. Gremlin, as a graph traversal machine, is composed of three interacting components: a graph $G$, a traversal $\Psi$, and a set of ...
Hartig O., Hopcroft J., Prud’hommeaux E., Rodriguez M. A., Rodriguez M. A., Shinavier J.   +5 more
core   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Are graph databases ready for bioinformatics? [PDF]

Bioinformatics, 2013
Abstract Contact:  Lars.Juhl.Jensen@gmail ...
Have, Christian Theil, Jensen, Lars Juhl
openaire   +4 more sources

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Towards open data blockchain analytics: a Bitcoin perspective [PDF]

Royal Society Open Science, 2018
Bitcoin is the first implementation of a technology that has become known as a ‘public permissionless’ blockchain. Such systems allow public read/write access to an append-only blockchain database without the need for any mediating central authority ...
D. McGinn, D. McIlwraith, Y. Guo
doaj   +1 more source

Creating an Intelligent System for Bankruptcy Detection: Semantic data Analysis Integrating Graph Database and Financial Ontology [PDF]

, 2019
In this paper, we propose a novel intelligent methodology to construct a Bankruptcy Prediction Computation Model, which is aimed to execute a company’s financial status analysis accurately.
Bolotov, A., Bolotov, A., Yerashenia, N., Yerashenia, N.   +3 more
core