Results 61 to 70 of about 810,661 (307)

Graph Locality Prefetcher for Graph Database [PDF]

, 2016
This work presents a hardware prefetcher to improve the performance of accessing graph data representing large and complex networks. We represent complex networks as graphs, and queries amount to traversals on the graph.
Yin, Zhuoran
core  

Anomaly Detection in Log Data using Graph Databases and Machine Learning to Defend Advanced Persistent Threats

, 2017
Advanced Persistent Threats (APTs) are a main impendence in cyber security of computer networks. In 2015, a successful breach remains undetected 146 days on average, reported by [Fi16].With our work we demonstrate a feasible and fast way to analyse real ...
Schindler, Timo
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Creating an Intelligent System for Bankruptcy Detection: Semantic data Analysis Integrating Graph Database and Financial Ontology [PDF]

, 2019
In this paper, we propose a novel intelligent methodology to construct a Bankruptcy Prediction Computation Model, which is aimed to execute a company’s financial status analysis accurately.
Bolotov, A., Bolotov, A., Yerashenia, N., Yerashenia, N.   +3 more
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Anatomy of a Data Science Software Toolkit That Uses Machine Learning to Aid ‘Bench-to-Bedside’ Medical Research—With Essential Concepts of Data Mining and Analysis Explained

Applied Sciences, 2021
Data science and machine learning are buzzwords of the early 21st century. Now pervasive through human civilization, how do these concepts translate to use by researchers and clinicians in the life-science and medical field?
László Beinrohr, Eszter Kail, Péter Piros, Erzsébet Tóth, Rita Fleiner, Krasimir Kolev   +5 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Extending Graph-Based Process Discovery for Hierarchical Block Detection and Incomplete Concurrent Relationship Handling

IEEE Access, 2023
The flow of business process activities in an organization can run simply in the form of sequential or complex in the form of choice and parallel. In the discovery process, parallel conditions can be deduced from the concurrent flows between activities ...
Indra Waspada, Riyanarto Sarno, Endang Siti Astuti, Hanung Nindito Prasetyo, Raden Budiraharjo   +4 more
doaj   +1 more source

Iteration Algebras for UnQL Graphs and Completeness for Bisimulation

, 2015
This paper shows an application of Bloom and Esik's iteration algebras to model graph data in a graph database query language. About twenty years ago, Buneman et al.
Hamana, Makoto
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source