Results 71 to 80 of about 810,661 (307)
The business of culture, a single subject community: lessons from The Culturist
Digital Studies, 2017 TheCulturist.ca is the result of a term long course within the Digital Humanities Minor for undergraduate students, worked on in collaboration with the CulturePlex Lab at Western University.
Antonio Jimenez-Mavillard +3 more
doaj +1 more source
Geospatial Data Management Research: Progress and Future Directions
ISPRS International Journal of Geo-Information, 2020 Without geospatial data management, today’s challenges in big data applications such as earth observation, geographic information system/building information modeling (GIS/BIM) integration, and 3D/4D city planning cannot be solved.
Martin Breunig +8 more
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Spatial search by quantum walk
, 2003 Grover's quantum search algorithm provides a way to speed up combinatorial search, but is not directly applicable to searching a physical database. Nevertheless, Aaronson and Ambainis showed that a database of N items laid out in d spatial dimensions can
A. Ambainis +9 more
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Towards open data blockchain analytics: a Bitcoin perspective [PDF]
Royal Society Open Science, 2018 Bitcoin is the first implementation of a technology that has become known as a ‘public permissionless’ blockchain. Such systems allow public read/write access to an append-only blockchain database without the need for any mediating central authority ...
D. McGinn, D. McIlwraith, Y. Guo
doaj +1 more source
Implementing Graph-based Search Engine using Sparksee Graph Database [PDF]
, 2015 The purpose of this project is to implement basic search engine which is based on graph data by using graph database. The data used in this project comes from the Marvel Chronology Project which includes all the characteristics in Marvel Universe and ...
Zhou, Jie
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
A graph database for persistent identifiers
, 2019 The Handle Software manages references to resources of information. However, it does not support a search functionality. A prior implementation with Elasticsearch could not efficiently capture the complex structure of our dataset, especially the relationships between handles.
Doan, Triet +5 more
openaire +2 more sources