Results 51 to 60 of about 388,640 (259)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A Brief Study of Open Source Graph Databases
, 2013 With the proliferation of large irregular sparse relational datasets, new storage and analysis platforms have arisen to fill gaps in performance and capability left by conventional approaches built on traditional database technologies and query languages.
Bader, David +4 more
core +2 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Context-Free Path Querying with Structural Representation of Result
, 2017 Graph data model and graph databases are very popular in various areas such as bioinformatics, semantic web, and social networks. One specific problem in the area is a path querying with constraints formulated in terms of formal grammars.
Afroozeh Ali +4 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
AN EMPIRICAL COMPARISON OF NEO4J AND TIGERGRAPH DATABASES FOR NETWORK CENTRALITY
Science Journal of University of Zakho, 2023 Graph databases have recently gained a lot of attention in areas where the relationships between data and the data itself are equally important, like the semantic web, social networks, and biological networks.
Bahzad Chicho +1 more
doaj +1 more source
Towards a query language for annotation graphs [PDF]
, 2000 The multidimensional, heterogeneous, and temporal nature of speech databases raises interesting challenges for representation and query. Recently, annotation graphs have been proposed as a general-purpose representational framework for speech databases ...
Bird, Steven +2 more
core +5 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Using SPARQL to access Linked Open Data
The Programming Historian, 2015 This lesson explains why many cultural institutions are adopting graph databases, and how researchers can access these data though the query language called SPARQL.
Matthew Lincoln
doaj
The Use of Graph Databases for Artificial Neural Networks
Journal of Advanced Research in Natural and Applied Sciences, 2021 Storing and using trained artificial neural network (ANN) models face technical difficulties. These models are usually stored as files and cannot be run directly. An artificial neural network can be structurally expressed as a graph.
Ahmet Cumhur Kınacı +1 more
doaj +1 more source