Results 71 to 80 of about 8,535,805 (358)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

On energy, Laplacian energy and p-fold graphs

Electronic Journal of Graph Theory and Applications, 2015
Summary: For a graph \(G\) having adjacency spectrum \((A\)-spectrum) \( \lambda_n\leq\lambda_{n-1}\leq\cdots\leq\lambda_1\) and Laplacian spectrum \((L\)-spectrum) \(0=\mu_n\leq\mu_{n-1}\leq\cdots\leq\mu_1\), the energy is defined as \(E(G)=\sum_{i=1}^n|\lambda_i|\) and the Laplacian energy is defined as \(LE(G)=\sum_{i=1}^n|\mu_i-\frac{2m}{n}|\).
Hilal A Ganie, Shariefuddin Pirzada, Edy Tri Baskoro   +2 more
openaire   +4 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Computing the Energy and Estrada Index of Different Molecular Structures

Journal of Chemistry, 2022
Graph energy is an invariant that is derived from the spectrum of the adjacency matrix of a graph. Graph energy is actually the absolute sum of all the eigenvalues of the adjacency matrix of a graph i.e.
Zeeshan Saleem Mufti, Rukhshanda Anjum, Qin Xin, Fairouz Tchier, Iram Anwar-ul-Haq, Yaé Ulrich Gaba   +5 more
doaj   +1 more source

Energy Minimization of Discrete Protein Titration State Models Using Graph Theory

, 2016
There are several applications in computational biophysics which require the optimization of discrete interacting states; e.g., amino acid titration states, ligand oxidation states, or discrete rotamer angles. Such optimization can be very time-consuming
Baker, Nathan A., Jurrus, Elizabeth, Monson, Kyle, Purvine, Emilie, Star, Keith   +4 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

An algorithm to prescribe the configuration of a finite graph [PDF]

, 2010
We provide algorithms involving edge slides, for a connected simple graph to evolve in a finite number of steps to another connected simple graph in a prescribed configuration, and for the regularization of such a graph by the minimization of an ...
Baird, Paul, Tiba, Marius
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Matrix Models on Large Graphs

, 1993
We consider the spherical limit of multi-matrix models on regular target graphs, for instance single or multiple Potts models, or lattices of arbitrary dimension. We show, to all orders in the low temperature expansion, that when the degree of the target
Ambjørn, Boulatov, Boulatov, Brézin, Brézin, Brézin, Erdodblac, Ginsparg, Gross, Kostov, Mark Wexler, Riordan, Wexler   +12 more
core   +2 more sources