Results 81 to 90 of about 5,808,675 (298)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
An Optimal Control Theory for the Traveling Salesman Problem and Its Variants [PDF]
, 2020 We show that the traveling salesman problem (TSP) and its many variants may be modeled as functional optimization problems over a graph. In this formulation, all vertices and arcs of the graph are functionals; i.e., a mapping from a space of measurable ...
Karpenko, M., Proulx, R. J., Ross, I. M.
core +1 more source
On Optimal Beyond-Planar Graphs
, 2022 Computing in Geometry and Topology, Vol. 2 No. 1 (2023)
openaire +3 more sources
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Frontiers in Complex SystemsResonance is a well-known phenomenon that happens in systems with second order dynamics. In this paper, we address the fundamental question of making a network robust to signal being periodically pumped into it at or near a resonant frequency by an ...
Alp Sahin +3 more
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
IVU-AutoNav: Integrated Visual and UWB Framework for Autonomous Navigation
DronesTo address the inherent scale ambiguity and positioning drift in monocular visual Simultaneous Localization and Mapping (SLAM), this paper proposes a novel localization method that integrates monocular visual SLAM with Ultra-Wideband (UWB) ranging ...
Shuhui Bu +4 more
doaj +1 more source
Robust Coloring Optimization Model on Electricity Circuit Problems
Jambura Journal of Mathematics, 2023 The Graph Coloring Problem (GCP) is assigning different colors to certain elements in a graph based on certain constraints and using a minimum number of colors.
Viona Prisyella Balqis +2 more
doaj +1 more source
Graphing an Optimal Grand Strategy
Military Operations Research, 1995 Graph theory provides a useful framework for generating insights into problems of sufficiency and optimality across a wide variety of physical relationships. Applied to the realm of grand strategy, this approach assists in developing a methodology for estimating the minimum level of forces required and determining the optimal deployments for the ...
Arquilla, John, Fredricksen, Hal
openaire +2 more sources
Uniformly optimally reliable graphs: A survey
Networks, 2021 AbstractWhich is the most reliable graph withnnodes andmedges? This celebrated problem has several aspects, according to the notion of optimality (in a local or uniform sense), failure type (either nodes or edges), or reliability model (all‐terminal connectedness, two‐terminal or multiterminal setting).
openaire +3 more sources